Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 5/20 | 0.47 |
| ▸ | BRAF | P15056 | 6/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.46 |
| ▸ | PIP4K2A | P48426 | 3/20 | 0.45 |
| ▸ | PIP4K2B | P78356 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 1/20 | 0.42 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3137063 | 0.87 | XDH (0.43) | SIRT2SIRT3SIRT1 | |
| SCHEMBL3151913 | 0.86 | MKNK1 (0.43) | CYP11B2CYP11B1CHEK2 | |
| SCHEMBL3141909 | 0.84 | XDH (0.42) | AKT1CHEK1FGFR1CHEK2 | |
| SCHEMBL3154853 | 0.84 | CHRNB2 (0.45) | AKT1SIRT2SIRT3SIRT1 | |
| SCHEMBL3780464 | 0.83 | AKT1 (0.44) | AKT1FYNBRAFSIRT2SIRT3 | |
| SCHEMBL3141387 | 0.82 | AKT1 (0.50) | AKT1FYNBRAFSIRT2SIRT3 | |
| SCHEMBL3137106 | 0.82 | EGLN1 (0.44) | CYP11B2 | |
| Hydrochloric Acid SCHEMBL3782980 | 0.81 | AKT1 (0.49) | AKT1FYNBRAFSIRT2SIRT3 | |
| SCHEMBL3780461 | 0.81 | AKT1 (0.46) | AKT1FYNBRAFSIRT2SIRT3 | |
| SCHEMBL3137105 | 0.81 | CHRNB1 (0.49) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |