Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.38 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3150645 | 0.88 | CYP11B1 (0.47) | BACE1CYP11B1CYP11B2 | |
| SCHEMBL3147229 | 0.87 | CHRNB2 (0.49) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| Hydrochloric Acid SCHEMBL3141660 | 0.87 | CYP11B1 (0.46) | BACE1CYP11B1CYP11B2 | |
| SCHEMBL3146014 | 0.87 | CHRNB1 (0.52) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3137054 | 0.87 | CYP11B2 (0.39) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3147306 | 0.87 | INPPL1 (0.43) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3141790 | 0.86 | CHRNB2 (0.48) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| Hydrochloric Acid SCHEMBL3765553 | 0.86 | CHRNB2 (0.48) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| Hydrochloric Acid SCHEMBL3773084 | 0.85 | CHRNB2 (0.47) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3137112 | 0.84 | GABRG2 (0.44) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |