Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3141578 | 0.76 | SLC13A5 (0.33) | STING1MTNR1AMTNR1B | |
| SCHEMBL7248539 | 0.73 | JAK2 (0.32) | JAK2JAK1JAK3 | |
| SCHEMBL5862668 | 0.67 | SLC13A5 (0.32) | STING1 | |
| SCHEMBL31700402 | 0.65 | BRD4 (0.33) | — | |
| SCHEMBL7359106 | 0.62 | MTNR1A (0.39) | JAK2JAK1JAK3MTNR1AMTNR1B | |
| SCHEMBL14829330 | 0.61 | ALDH1A1 (0.52) | JAK2JAK3 | |
| SCHEMBL14848190 | 0.60 | NAPRT (0.48) | — | |
| Hydrochloric Acid SCHEMBL27340187 | 0.60 | RAB9A (0.45) | MTNR1AMTNR1B | |
| SCHEMBL7413081 | 0.59 | PDPK1 (0.39) | — | |
| SCHEMBL18152647 | 0.59 | CYP19A1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007386-B1 | CAMPTOTHECIN-ANALOG WITH A NOVEL, FLIPPED LACTONE-STABLE, E-RING AND METHODS FOR MAKING AND USING SAME | BIONUMERIK PHARMACEUTICALS INC (US) | 2012-08-22 | — | — | EP | disclosed |
| US-7687487-B2 | Camptothecin-analog with a novel, “flipped” lactone-stable, E-ring and methods for making and using same | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687487-B2 | Camptothecin-analog with a novel, “flipped” lactone-stable, E-ring and methods for making and using same | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687487-B2 | Camptothecin-analog with a novel, “flipped” lactone-stable, E-ring and methods for making and using same | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2010-03-30 | — | — | US | disclosed |
| EP-2007386-A2 | CAMPTOTHECIN-ANALOG WITH A NOVEL, FLIPPED LACTONE-STABLE, E-RING AND METHODS FOR MAKING AND USING SAME | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2008-12-31 | — | — | EP | disclosed |
| US-20080261919-A1 | Camptothecin-analog with a novel, \"flipped\" lactone-stable, E-ring and methods for making and using same | BIONUMERIK PHARMACEUTICALS, INC. | 2008-10-23 | — | — | US | disclosed |
| US-20080261919-A1 | Camptothecin-analog with a novel, \"flipped\" lactone-stable, E-ring and methods for making and using same | BIONUMERIK PHARMACEUTICALS, INC. | 2008-10-23 | — | — | US | disclosed |
| US-20080261919-A1 | Camptothecin-analog with a novel, \"flipped\" lactone-stable, E-ring and methods for making and using same | BIONUMERIK PHARMACEUTICALS, INC. | 2008-10-23 | — | — | US | disclosed |
| WO-2007123995-A2 | CAMPTOTHECIN-ANALOG WITH A NOVEL, “FLIPPED” LACTONE-STABLE, E-RING AND METHODS FOR MAKING AND USING SAME | BIONUMERIK PHARMACEUTICALS, INC. (US) | 2007-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261919-A1 | Camptothecin-analog with a novel, \"flipped\" lactone-stable, E-ring and methods for making and using same | PAICS, FAU, FOLR1 | JAK2 3712/4885JAK1 4297/4885JAK3 4141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.