Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31416849 | 0.81 | ALDH1A1 (0.40) | TLR8TLR7KCNH2MCHR1HRH3 | |
| SCHEMBL31416817 | 0.79 | NOS3 (0.38) | — | |
| SCHEMBL20509326 | 0.77 | TLR8 (0.37) | TLR8TLR7KCNH2MCHR1HRH3 | |
| SCHEMBL31416767 | 0.75 | CXCR4 (0.36) | TLR8TLR7KCNH2MCHR1HRH3 | |
| SCHEMBL24046712 | 0.75 | CYP11B1 (0.34) | TLR8TLR7KCNH2MCHR1HRH3 | |
| SCHEMBL30351050 | 0.75 | LMNA (0.37) | TLR8TLR7KCNH2MCHR1HRH3 | |
| SCHEMBL14764263 | 0.74 | TLR8 (0.39) | TLR8TLR7KCNH2MCHR1HRH3 | |
| SCHEMBL31416784 | 0.74 | KCNH2 (0.34) | KCNH2MCHR1 | |
| SCHEMBL34471630 | 0.71 | GRM2 (0.38) | TLR8TLR7HRH3MBOAT4 | |
| SCHEMBL18202729 | 0.70 | ALDH1A1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4746964-A1 | NEW PYRAZOLOPYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2026-05-27 | — | — | EP | disclosed |
| WO-2026046976-A1 | PYRAZOLOPYRIDINE PHOSPHATE ESTERS FOR MODULATING SALT-INDUCIBLE KINASE (SIK) | F. HOFFMANN-LA ROCHE AG (CH) | 2026-03-05 | — | — | WO | disclosed |
| WO-2025017078-A1 | NEW PYRAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2025-01-23 | — | — | WO | disclosed |