Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | VEGFA | P15692 | 3/20 | 0.41 |
| ▸ | FLT1 | P17948 | 3/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.41 |
| ▸ | TET3 | O43151 | 1/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.41 |
| ▸ | ASPH | Q12797 | 1/20 | 0.41 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.41 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.41 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.41 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.41 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3150661 | 0.89 | CYP11B2 (0.35) | XDHSLC22A12GSK3BMKNK2AKT1 | |
| SCHEMBL3137063 | 0.88 | XDH (0.43) | XDHSLC22A12EGLN1GSK3BMKNK2 | |
| SCHEMBL3155830 | 0.88 | SCN10A (0.42) | XDHSLC22A12EGLN1EGLN3MKNK2 | |
| SCHEMBL3151913 | 0.88 | MKNK1 (0.43) | KDRCHEK2GSK3BMKNK2MAPT | |
| SCHEMBL3154853 | 0.88 | CHRNB2 (0.45) | AXLCDK7MKNK2AKT1 | |
| SCHEMBL3151273 | 0.86 | NR1H4 (0.39) | JAK2 | |
| SCHEMBL3138280 | 0.85 | CHRNB1 (0.38) | — | |
| SCHEMBL3137106 | 0.85 | EGLN1 (0.44) | EGLN1AXL | |
| SCHEMBL3145805 | 0.84 | AKT1 (0.49) | CHEK1CHEK2FGFR1AKT1 | |
| SCHEMBL3137105 | 0.84 | CHRNB1 (0.49) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |