Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3142217 | 1.00 | MAPT (0.58) | MAPTKMT2AKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL3191872 | 0.85 | GPR35 (0.39) | MAPTKMT2AKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL28755742 | 0.78 | CTSB (0.51) | MAPTKMT2ASMN1; SMN2MEN1NPC1 | |
| SCHEMBL5838349 | 0.77 | NPC1 (0.59) | MAPTKMT2AKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL28436497 | 0.77 | MAPT (0.59) | MAPTKMT2AKDM4EMEN1NPC1 | |
| SCHEMBL24213305 | 0.77 | NPC1 (0.59) | MAPTKMT2AKDM4ESMN1; SMN2MEN1 | |
| Nitrophenolate SCHEMBL27457258 | 0.77 | NPC1 (0.59) | MAPTKMT2AKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL5838346 | 0.77 | NPC1 (0.59) | MAPTKMT2AKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL6129303 | 0.76 | NPC1 (0.58) | MAPTKMT2AKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL8557082 | 0.76 | MEN1 (0.42) | MAPTKMT2AKDM4ESMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642358-B2 | Substituted phenylacetic acids | METABOLEX, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-20060264630-A1 | Substituted phenylacetic acids | METABOLEX, INC. (US) | 2006-11-23 | — | — | US | disclosed |
| US-7078421-B2 | Substituted phenylacetic acids | METABOLEX, INC. (US) | 2006-07-18 | — | — | US | disclosed |
| EP-1487843-A2 | SUBSTITUTED PHENYLACETIC ACIDS | Metabolex, Inc. (US) | 2004-12-22 | — | — | EP | disclosed |
| US-20040029933-A1 | Substituted phenylacetic acids | METABOLEX, INC. | 2004-02-12 | — | — | US | disclosed |
| WO-2003080545-A2 | SUBSTITUTED PHENYLACETIC ACIDS | METABOLEX, INC. (US) | 2003-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040029933-A1 | Substituted phenylacetic acids | PNLIP, PC, PAOX | MAPT 2832/4885KMT2A 1635/4885KDM4E 3805/4885 |
| US-20060264630-A1 | Substituted phenylacetic acids | PNLIP, PC, PAOX | MAPT 2832/4885KMT2A 1635/4885KDM4E 3805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.