Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.61 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.58 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.44 |
| ▸ | PRKCA | P17252 | 2/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1781915 | 1.00 | HSD11B1 (0.61) | HSD11B1GNEHSD17B14KDM4EALOX15 | |
| SCHEMBL836939 | 0.98 | GNE (0.60) | HSD11B1GNEHSD17B14KDM4EALOX15 | |
| SCHEMBL14879835 | 0.95 | GNE (0.56) | HSD11B1GNEHSD17B14KDM4EALOX15 | |
| SCHEMBL27896675 | 0.88 | HSD17B14 (0.64) | HSD11B1GNEHSD17B14CNR1PRKCQ | |
| SCHEMBL12469440 | 0.85 | PRKCA (0.62) | HSD11B1GNEHSD17B14KDM4EALOX15 | |
| SCHEMBL10002521 | 0.84 | HSD11B1 (0.58) | HSD11B1HSD17B14KDM4ETSHRCNR1 | |
| SCHEMBL1779262 | 0.83 | KMO (0.55) | HSD11B1GNEKDM4EALOX15TSHR | |
| SCHEMBL29483989 | 0.83 | KMO (0.55) | HSD11B1GNEKDM4EALOX15TSHR | |
| SCHEMBL2638000 | 0.83 | HTR3A (0.58) | HSD11B1GNEHSD17B14KDM4EALOX15 | |
| SCHEMBL27415238 | 0.83 | PRKCA (0.59) | HSD11B1GNEKDM4EALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025049326-A1 | TRICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | BIOCRYST PHARMACEUTICALS, INC. (US) | 2025-03-06 | — | — | WO | disclosed |