Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 4/20 | 0.44 |
| ▸ | PRKDC | P78527 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7092074 | 0.84 | SMN1; SMN2 (0.61) | ALDH1A1TSHRKDM4ETDP1POLB | |
| SCHEMBL5789989 | 0.83 | MAPT (0.58) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 | |
| SCHEMBL7917725 | 0.83 | ALDH1A1 (0.48) | ALDH1A1TSHRKDM4ETDP1POLB | |
| SCHEMBL11380066 | 0.83 | ALDH1A1 (0.48) | ALDH1A1TSHRKDM4ETDP1POLB | |
| SCHEMBL7914200 | 0.83 | PTGS2 (0.50) | ALDH1A1TSHRKDM4ETDP1POLB | |
| SCHEMBL7804821 | 0.81 | ALDH1A1 (0.47) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 | |
| SCHEMBL7914197 | 0.80 | L3MBTL1 (0.47) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 | |
| SCHEMBL7810581 | 0.80 | ALDH1A1 (0.46) | ALDH1A1TSHRKDM4ETDP1POLB | |
| SCHEMBL7820153 | 0.80 | ALDH1A1 (0.62) | ALDH1A1TSHRKDM4EL3MBTL1POLB | |
| SCHEMBL29164334 | 0.80 | MAPK1 (0.70) | TSHRPOLBMAPK1ALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250074942-A1 | COMPOSITIONS AND METHODS FOR COVALENT PEPTIDE-BASED MODULATORS OF HLA-E | CALICO LIFE SCIENCES LLC (US) | 2025-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250074942-A1 | COMPOSITIONS AND METHODS FOR COVALENT PEPTIDE-BASED MODULATORS OF HLA-E | MICA, CD74, HLA-DRB1 | ALDH1A1 3213/4885TSHR 4329/4885KDM4E 691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.