Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Argatroban. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 7/20 | 0.82 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.77 |
| ▸ | F10 | P00742 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | PLAT | P00750 | 1/20 | 0.77 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.77 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Argatroban SCHEMBL4308143 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL1145427 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL29572887 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL6852675 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL3175687 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL4933701 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL1817517 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL4374 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL1145308 | 0.99 | F2 (0.83) | F2PRSS1F10LMNAPLAT | |
| Argatroban SCHEMBL23356536 | 0.99 | F2 (0.82) | F2PRSS1F10LMNAPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130023559-A1 | ALCOHOL FREE FORMULATION OF ARGATROBAN | EAGLE PHARMACEUTICALS, INC. (US) | 2013-01-24 | — | — | US | disclosed |
| US-7687516-B2 | Alcohol free formulation of argatroban | EAGLE PHARMACEUTICALS, INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-20100076019-A1 | ALCOHOL FREE FORMULATION OF ARGATROBAN | EAGLE PHARMACEUTICALS, INC. (US) | 2010-03-25 | — | — | US | disclosed |
| US-7589106-B2 | Alcohol free formulation of argatroban | EAGLE PHARMACEUTICALS, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| EP-2083823-A2 | ALCOHOL FREE FORMULATION OF ARGATROBAN | Scidose, Llc (US) | 2009-08-05 | — | — | EP | disclosed |
| US-20080300272-A1 | Alcohol free formulation of argatroban | EAGLE PHARMACEUTICALS, INC. | 2008-12-04 | — | — | US | disclosed |
| WO-2008045410-A2 | ALCOHOL FREE FORMULATION OF ARGATROBAN | SCIDOSE LLC (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2008039473-A2 | ALCOHOL FREE FORMULATION OF ARGATROBAN | SCIDOSE LLC (US) | 2008-04-03 | — | — | WO | disclosed |
| US-20080076798-A1 | Alcohol free formulation of argatroban | SCIDOSE LLC | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076019-A1 | ALCOHOL FREE FORMULATION OF ARGATROBAN | MMAB, ADH1A, ITGB6 | F2 65/4885PRSS1 1764/4885F10 401/4885 |
| US-20080300272-A1 | Alcohol free formulation of argatroban | MMAB, ADH1A, AADAT | F2 62/4885PRSS1 1833/4885F10 408/4885 |
| US-20130023559-A1 | ALCOHOL FREE FORMULATION OF ARGATROBAN | MMAB, ADH1A, ITGB6 | F2 65/4885PRSS1 1764/4885F10 401/4885 |
| US-20080076798-A1 | Alcohol free formulation of argatroban | MMAB, ADH1A, AADAT | F2 62/4885PRSS1 1833/4885F10 408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.