SCHEMBL3146037

SCHEMBL3146037

COc1ccc(-c2cncc(OCC3(N(C)C(=O)O)CC3)c2)cc1

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAP4K4 O95819 2/20 0.45
MKNK1 Q9BUB5 1/20 0.45
MKNK2 Q9HBH9 1/20 0.45
CHRNB1 P11230 1/20 0.44
CHRNB2 P17787 1/20 0.44
CHRNB4 P30926 1/20 0.44
CHRNA3 P32297 1/20 0.44
CHRNB3 Q05901 1/20 0.44
CYP11B1 P15538 7/20 0.44
CYP11B2 P19099 7/20 0.44
CYP1A2 P05177 2/20 0.40
CYP3A4 P08684 2/20 0.40
CYP2C9 P11712 1/20 0.40
GSK3B P49841 1/20 0.39
DYRK1A Q13627 1/20 0.39
KDM1A O60341 1/20 0.39
HDAC1 Q13547 1/20 0.39
FYN P06241 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3772192 0.90 CHRNB2 (0.43) MAP4K4MKNK1MKNK2CHRNB1CHRNB2
SCHEMBL3146952 0.90 CHRNB2 (0.44) MKNK1MKNK2CHRNB1CHRNB2CHRNB4
SCHEMBL3151919 0.89 CYP11B1 (0.42) MKNK1MKNK2CYP11B1CYP11B2CYP1A2
SCHEMBL3155835 0.89 CHRNB1 (0.44) MAP4K4MKNK1MKNK2CHRNB1CHRNB2
SCHEMBL3150649 0.88 XDH (0.37) MKNK1MKNK2CHRNB1CHRNB2CHRNB4
SCHEMBL3142660 0.87 MKNK1 (0.36) MKNK1MKNK2CHRNB1CHRNB2CHRNB4
SCHEMBL3146059 0.86 XDH (0.43) MAP4K4CHRNB2CYP11B1CYP11B2KDM1A
SCHEMBL3260280 0.85 CHRNB1 (0.39) MKNK1MKNK2CHRNB1CHRNB2CHRNB4
SCHEMBL3774204 0.85 ACVR1 (0.38) MKNK1MKNK2CYP11B2FYN
SCHEMBL3150665 0.83 CYP11B2 (0.35) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1979321-B9 NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SERVIER LAB (FR) 2010-02-17 EP disclosed
EP-1979321-B1 NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SERVIER LAB (FR) 2009-07-29 EP disclosed