Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 2/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.33 |
| ▸ | INPPL1 | O15357 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3155835 | 0.90 | CHRNB1 (0.44) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3141913 | 0.89 | XDH (0.42) | XDHSLC22A12 | |
| SCHEMBL3146952 | 0.86 | CHRNB2 (0.44) | CYP11B2CHRNB2CHRNA4CHRNB1CHRNB4 | |
| SCHEMBL3151280 | 0.86 | NR1H4 (0.39) | XDHSLC22A12 | |
| SCHEMBL3138285 | 0.85 | CHRNB1 (0.40) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3772192 | 0.84 | CHRNB2 (0.43) | CYP11B2CHRNB2CHRNA4CHRNB1CHRNB4 | |
| SCHEMBL3780631 | 0.84 | CYP11B2 (0.33) | CYP11B2CHRNB2CHRNA4CHRNB1CHRNB4 | |
| SCHEMBL3774204 | 0.84 | ACVR1 (0.38) | CYP11B2 | |
| SCHEMBL3146037 | 0.83 | MAP4K4 (0.45) | CYP11B2CHRNB2CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL3150649 | 0.82 | XDH (0.37) | CYP11B2CHRNB2CHRNA4CHRNB1CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |