Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.45 |
| ▸ | CA2 | P00918 | 5/20 | 0.45 |
| ▸ | CA4 | P22748 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CA6 | P23280 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6865388 | 1.00 | CA1 (0.45) | CA1CA2CA4KMT2ACA6 | |
| SCHEMBL14228794 | 0.98 | KMT2A (0.47) | CA1CA2CA4KMT2ACA6 | |
| Hydrochloric Acid SCHEMBL3120247 | 0.98 | CA1 (0.43) | CA1CA2CA4KMT2ACA6 | |
| Hydrochloric Acid SCHEMBL28863686 | 0.98 | CA1 (0.43) | CA1CA2CA4KMT2ACA6 | |
| SCHEMBL4631860 | 0.98 | KMT2A (0.47) | CA1CA2CA4KMT2ACA6 | |
| SCHEMBL4631229 | 0.98 | KMT2A (0.47) | CA1CA2CA4KMT2ACA6 | |
| SCHEMBL6865770 | 0.94 | HTR6 (0.39) | CA1CA2CA4KMT2ANPC1 | |
| SCHEMBL4631245 | 0.94 | HTR6 (0.39) | CA1CA2CA4KMT2ANPC1 | |
| SCHEMBL13948191 | 0.86 | CA1 (0.41) | CA1CA2CA4KMT2ACA6 | |
| SCHEMBL13899831 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 209 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118108610-B | Preparation method of nortramadol hydrochloride | 山东新华制药股份有限公司 | 2025-01-10 | — | — | CN | claimed |
| CN-118108610-A | Preparation method of nortramadol hydrochloride | 山东新华制药股份有限公司 | 2024-05-31 | — | — | CN | claimed |
| CN-114292199-A | Preparation method of tramadol hydrochloride impurity C | 深圳市祥根生物医药有限公司 | 2022-04-08 | — | — | CN | claimed |
| US-7470816-B2 | Tramadol recovery process | IPAC LABORATORIES LIMITED (IN) | 2008-12-30 | — | — | US | claimed |
| EP-1438284-B1 | SYNTHESIS OF ( )-2-((DIMETHYLAMINO)METHYL)-1-(ARYL)CYCLOHEXANOLS | EURO CELTIQUE SA (LU) | 2007-09-26 | — | — | EP | claimed |
| US-20070112074-A1 | Tramadol recovery process | IPCA LABORATORIES LIMITED (IN) | 2007-05-17 | — | — | US | claimed |
| EP-1785412-A1 | Tramadol recovery process | IPCA Laboratories Limited (IN) | 2007-05-16 | — | — | EP | claimed |
| EP-1527043-B1 | METHOD FOR THE PRODUCTION OF 2- (DIMETHYLAMINO)METHYL|-1-(3-METHOXYPHENYL)CYCLOHEXANOL | GRUENENTHAL GMBH (DE) | 2006-10-04 | — | — | EP | claimed |
| US-7030276-B2 | Process for preparing 2-[(dimethylamino)-methyl]-1-(3-methoxyphenyl)cyclohexanol | GRUENENTHAL GMBH (DE) | 2006-04-18 | — | — | US | claimed |
| US-20050215821-A1 | Process for preparing 2-[(dimethylamino)-methyl]-1-(3-methoxyphenyl)cyclohexanol | GRUENENTHAL GMBH (DE) | 2005-09-29 | — | — | US | claimed |
| EP-0996613-B1 | PURE CIS-TRAMADOL HYDROCHLORIDE PRODUCTION | RUSSINSKY LTD (IE) | 2002-10-30 | — | — | EP | claimed |
| US-6469213-B1 | FORMING TRAMADOL MANNICH BASE, FORMING CIS-TRAMADOL BASE HYDRATE FROM THE TRAMADOL MANNICH BASE, AND FORMING CIS-TRAMADOL HYDROCHLORIDE FROM THE CIS-TRAMADOL BASE HYDRATE | RUSSINSKY LIMITED (IE) | 2002-10-22 | — | — | US | claimed |
| EP-0778262-B1 | Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl)cyclohexanol and its salts | CHEMAGIS LTD (IL) | 2001-01-24 | — | — | EP | claimed |
| EP-1047662-A1 | PURIFICATION OF TRAMADOL | MACFARLAN SMITH LIMITED (GB) | 2000-11-02 | — | — | EP | claimed |
| WO-1999036390-A1 | PURIFICATION OF TRAMADOL | MACFARLAN SMITH LIMITED (GB) | 1999-07-22 | — | — | WO | claimed |
| WO-1999036389-A1 | PURIFICATION OF TRAMADOL | MACFARLAN SMITH LIMITED (GB) | 1999-07-22 | — | — | WO | claimed |
| US-5877351-A | REACTION WITH HYDROGEN BROMIDE | WYCKOFF CHEMICAL COMPANY, INC. (US) | 1999-03-02 | — | — | US | claimed |
| US-5730996-A | Intercalates and expoliates formed with organic pesticide compounds and compositions containing the same | AMCOL INTERNATIONAL CORPORATION (US) | 1998-03-24 | — | — | US | claimed |
| US-5672755-A | Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl)cyclohexanol and its salts | CHEMAGIS LTD. (IL) | 1997-09-30 | — | — | US | claimed |
| EP-0778262-A2 | Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl)cyclohexanol and its salts | Chemagis Ltd. (IL) | 1997-06-11 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112074-A1 | Tramadol recovery process | TRAM1, OPRK1, SLC6A6 | CA1 2464/4885CA2 1115/4885CA4 3143/4885 |
| US-20050215821-A1 | Process for preparing 2-[(dimethylamino)-methyl]-1-(3-methoxyphenyl)cyclohexanol | DGKA, DEGS1, GRIK2 | CA1 3393/4885CA2 1524/4885CA4 2171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.