Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | PDIA6 | Q15084 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6656968 | 0.88 | DRD2 (0.53) | DRD2DRD4DRD3RAB9ANPC1 | |
| SCHEMBL3763682 | 0.87 | DRD2 (0.58) | DRD2DRD4DRD3RAB9ANPC1 | |
| SCHEMBL17637581 | 0.85 | DRD2 (0.61) | DRD2DRD4DRD3RAB9ANPC1 | |
| SCHEMBL25261232 | 0.84 | SMN1; SMN2 (0.49) | DRD2DRD4DRD3RAB9ANPC1 | |
| SCHEMBL18472260 | 0.84 | MRGPRX4 (0.46) | DRD2DRD4DRD3RAB9ANPC1 | |
| SCHEMBL26023458 | 0.84 | NPC1 (0.48) | DRD2DRD4DRD3RAB9ANPC1 | |
| SCHEMBL4608317 | 0.82 | NPC1 (0.45) | DRD2DRD4DRD3RAB9ANPC1 | |
| SCHEMBL4608319 | 0.82 | PDIA6 (0.44) | DRD2DRD4DRD3RAB9ANPC1 | |
| SCHEMBL15760678 | 0.81 | KDM4E (0.53) | DRD2DRD4DRD3RAB9ANPC1 | |
| SCHEMBL469900 | 0.81 | DRD2 (0.53) | DRD2DRD4DRD3RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371322-B2 | Bicyclic aza-amides for treatment of psychiatric disorders | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2016-06-21 | — | — | US | disclosed |
| US-20150183786-A1 | BICYCLIC AZA-AMIDES FOR TREATMENT OF PSYCHIATRIC DISORDERS | MAX-PLANCK-GESSELSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. (DE) | 2015-07-02 | — | — | US | disclosed |
| US-7671089-B2 | Levodopa prodrugs, and compositions and uses thereof | XENOPORT, INC. (US) | 2010-03-02 | — | — | US | disclosed |
| US-20100004332-A1 | Levodopa Prodrugs, and Compositions and Uses Thereof | XENOPORT, INC. (US) | 2010-01-07 | — | — | US | disclosed |
| US-20080103200-A1 | Levodopa prodrugs, and compositions and uses thereof | XENOPORT, INC. (US) | 2008-05-01 | — | — | US | disclosed |
| US-7323585-B2 | Levodopa prodrugs, and compositions and uses thereof | XENOPORT, INC. (US) | 2008-01-29 | — | — | US | disclosed |
| US-20060020028-A1 | Levodopa prodrugs, and compositions and uses thereof | ARBOR PHARMACEUTICALS, LLC | 2006-01-26 | — | — | US | disclosed |
| WO-2005121070-A1 | LEVODOPA PRODRUGS, AND COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2005-12-22 | — | — | WO | disclosed |
| EP-0874805-B1 | PHENYLACETAMIDE DERIVATIVES | KOREA RES INST CHEM TECH (KR) | 2000-09-20 | — | — | EP | disclosed |
| US-5973201-A | ANALGESICS; ANTIINFLAMMATORY AGENTS | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1999-10-26 | — | — | US | disclosed |
| EP-0874805-A1 | PHENYLACETAMIDE DERIVATIVES | Korea Research Institute of Chemical Technology (KR) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997021668-A1 | PHENYLACETAMIDE DERIVATIVES | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1997-06-19 | — | — | WO | disclosed |
| US-5090994-A | HETEROCYCLIC COMPOUNDS AND HERBICIDAL COMPOSITIONS CONTAINING THE COMPOUNDS AS EFFECTIVE COMPONENTS | AGRO-KANESHO CO., LTD. (JP) | 1992-02-25 | — | — | US | disclosed |
| EP-0384973-A2 | Heterocyclic compounds, method for preparing the same and herbicidal compositions containing the compounds as effective components | AGRO-KANESHO CO., LTD. (JP) | 1990-09-05 | — | — | EP | disclosed |
| EP-0252876-A1 | Hydrogenated 1-phenoxyalkylpyridine-3-carboxylic-acid compounds | CIBA-GEIGY AG (CH) | 1988-01-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060020028-A1 | Levodopa prodrugs, and compositions and uses thereof | COMT, DDT, DDC | DRD2 70/4885DRD4 109/4885DRD3 144/4885 |
| US-20080103200-A1 | Levodopa prodrugs, and compositions and uses thereof | COMT, DDT, DDC | DRD2 70/4885DRD4 109/4885DRD3 144/4885 |
| US-20150183786-A1 | BICYCLIC AZA-AMIDES FOR TREATMENT OF PSYCHIATRIC DISORDERS | BDNF, MAOA, HDAC10 | DRD2 111/4885DRD4 568/4885DRD3 380/4885 |
| US-20100004332-A1 | Levodopa Prodrugs, and Compositions and Uses Thereof | COMT, DDT, DDC | DRD2 70/4885DRD4 109/4885DRD3 144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.