Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL31467787 | 0.86 | TDP1 (0.43) | MMP2MMP9TDP1L3MBTL1CHRM2 | |
| Bromide SCHEMBL20541445 | 0.85 | TDP1 (0.58) | TDP1L3MBTL1CHRM2 | |
| Bromide SCHEMBL20541913 | 0.85 | TDP1 (0.58) | TDP1L3MBTL1CHRM2 | |
| Bromide SCHEMBL20541389 | 0.85 | TDP1 (0.58) | TDP1L3MBTL1CHRM2 | |
| Bromide SCHEMBL20541546 | 0.85 | TDP1 (0.58) | TDP1L3MBTL1CHRM2 | |
| Bromide SCHEMBL1579652 | 0.85 | TDP1 (0.58) | TDP1L3MBTL1CHRM2 | |
| Bromide SCHEMBL1325100 | 0.83 | TDP1 (0.55) | TDP1L3MBTL1HDAC1HDAC7 | |
| Bromide SCHEMBL30438216 | 0.80 | RAB9A (0.56) | CHRM2 | |
| Bromide SCHEMBL20541573 | 0.80 | RAB9A (0.56) | CHRM2 | |
| Bromide SCHEMBL517469 | 0.79 | TDP1 (0.53) | TDP1L3MBTL1CHRM2HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250042925-A1 | Improved Compositions and Methods for Targeting Mitochondria in Cancer Cells | NATIONAL INSTITUTES OF HEALTH | 2025-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250042925-A1 | Improved Compositions and Methods for Targeting Mitochondria in Cancer Cells | TFAM, UQCRC2, NDUFAB1 | CHRM2 4664/4885MMP2 1894/4885MMP9 2822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.