SCHEMBL31469347

SCHEMBL31469347

CC1(C)OB(c2c(-c3ccccc3)ncn2COCC[Si](C)(C)C)OC1(C)C

nearest known ligand 0.39

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
LPL P06858 1/20 0.39
LIPG Q9Y5X9 1/20 0.39
DGAT1 O75907 5/20 0.34
BRD4 O60885 1/20 0.33
CREBBP Q92793 1/20 0.33
PTGS2 P35354 1/20 0.32
F11 P03951 1/20 0.30
KEAP1 Q14145 1/20 0.30
NFE2L2 Q16236 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4064723 0.78 PTGS2 (0.50) DGAT1PTGS2
SCHEMBL31469288 0.77 DGAT1 (0.42) DGAT1BRD4CREBBPPTGS2F11
SCHEMBL31469232 0.77 LIPG (0.40) LPLLIPGDGAT1F11KEAP1
SCHEMBL26694207 0.76 DGAT1 (0.32) DGAT1BRD4CREBBP
SCHEMBL4799731 0.74 PTGS2 (0.43) DGAT1PTGS2F11
SCHEMBL22862956 0.73 DGAT1 (0.42) DGAT1BRD4CREBBPPTGS2F11
SCHEMBL27251338 0.73 BRD4 (0.33) DGAT1BRD4CREBBP
SCHEMBL9583448 0.71 BRD4 (0.35) DGAT1BRD4CREBBPPTGS2F11
SCHEMBL9583407 0.71 RPS6KA5 (0.37) DGAT1BRD4CREBBPPTGS2F11
SCHEMBL1271939 0.70 IRAK4 (0.34) LPLLIPGDGAT1BRD4CREBBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025080784-A1 EGFR INHIBITORS BLUEPRINT MEDICINES CORPORATION (US) 2025-04-17 WO disclosed