Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Pbt-434. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pbt-434 SCHEMBL30080956 | 0.95 | TLR7 (0.39) | TLR7CDK1CCNB1CCNE1CDK2 | |
| Pbt-434 SCHEMBL7905166 | 0.95 | TLR7 (0.39) | TLR7CDK1CCNB1CCNE1CDK2 | |
| Pbt-434 SCHEMBL31470112 | 0.94 | TLR7 (0.39) | TLR7CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL7896656 | 0.83 | TLR7 (0.34) | TLR7 | |
| SCHEMBL7906718 | 0.82 | TLR7 (0.35) | TLR7 | |
| SCHEMBL7897343 | 0.81 | CTSB (0.31) | TLR7CDK1 | |
| SCHEMBL7895830 | 0.79 | HSD17B13 (0.36) | TLR7 | |
| SCHEMBL31470105 | 0.79 | TLR7 (0.38) | TLR7 | |
| SCHEMBL7895550 | 0.79 | TLR7 (0.33) | TLR7 | |
| SCHEMBL7904691 | 0.76 | LMNA (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025059726-A1 | NOVEL THERAPY | Alterity Therapeutics Limited (AU) | 2025-03-27 | — | — | WO | disclosed |