SCHEMBL31474545

SCHEMBL31474545

CC(=O)c1ccc(C(=O)NCC#N)cc1

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.50
NR1H4 Q96RI1 1/20 0.50
NAMPT P43490 1/20 0.50
CTSL P07711 8/20 0.46
KMT2A Q03164 2/20 0.45
ALDH1A1 P00352 1/20 0.45
MAPT P10636 1/20 0.45
CTSB P07858 4/20 0.44
CTSK P43235 4/20 0.44
CTSS P25774 4/20 0.44
MRGPRX4 Q96LA9 1/20 0.44
MEN1 O00255 1/20 0.44
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA9 Q16790 1/20 0.44
CA14 Q9ULX7 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10451394 0.85 LMNA (0.58) NAMPTCTSLKMT2AALDH1A1MAPT
SCHEMBL9827345 0.83 CTSL (0.61) EPHX2NAMPTCTSLKMT2AALDH1A1
SCHEMBL26261156 0.83 MEN1 (0.62) EPHX2NAMPTKMT2AALDH1A1MAPT
SCHEMBL10764773 0.83 CTSL (0.59) NAMPTCTSLALDH1A1CTSBCTSK
SCHEMBL9873510 0.83 CYP1A2 (0.56) NAMPTKMT2AALDH1A1MAPTCTSB
SCHEMBL17011384 0.83 KDM4E (0.58) EPHX2NAMPTCTSLKMT2AALDH1A1
SCHEMBL2863808 0.82 GAA (0.61) NAMPTCTSLALDH1A1CTSBCTSK
SCHEMBL10076235 0.81 PLK1 (0.59) EPHX2NAMPTCTSLALDH1A1MAPT
SCHEMBL21652280 0.81 EPHX2 (0.61) EPHX2NR1H4KMT2AALDH1A1MAPT
SCHEMBL2156507 0.81 NAMPT (0.47) NAMPTCTSLKMT2ACTSBCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119591550-A Preparation method of molatinib and key intermediate 沈阳药科大学 2025-03-11 CN disclosed