SCHEMBL31476885

SCHEMBL31476885

O=C(O)Cc1ccc(F)c(OCCOCCNc2cccc(C(=O)O)c2CNC2CCC(=O)NC2=O)c1

nearest known ligand 0.39

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CD274 Q9NZQ7 1/20 0.39
CRBN Q96SW2 15/20 0.37
STAT3 P40763 4/20 0.35
DDB1 Q16531 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27354582 0.85 CRBN (0.43) CD274CRBNSTAT3DDB1
SCHEMBL31476929 0.80 ALDH1A1 (0.39) CD274
SCHEMBL31476875 0.75 WDR5 (0.38)
SCHEMBL27355334 0.71 STAT3 (0.59) CRBNSTAT3DDB1
SCHEMBL19451274 0.69 DYRK2 (0.39) CD274CRBNSTAT3DDB1
SCHEMBL27354577 0.67 PPARA (0.37)
SCHEMBL27354578 0.66 PPARA (0.36)
SCHEMBL31457827 0.65 STAT3 (0.63) CRBNSTAT3DDB1
SCHEMBL31457806 0.65 LRRK2 (0.49) CRBNSTAT3DDB1
SCHEMBL6730357 0.65 CRBN (0.63) CRBNDDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119730847-A NRF2 protein degradation agent 盖尼米德肿瘤学股份有限公司 2025-03-28 CN disclosed