Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | PYGL | P06737 | 8/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3129297 | 0.86 | KDM4E (0.60) | KDM4EMAPTHPGDNPC1RAB9A | |
| SCHEMBL15471930 | 0.85 | ALDH1A1 (0.68) | KDM4EMAPTHPGDNPC1RAB9A | |
| SCHEMBL3140116 | 0.82 | KDM4E (0.55) | KDM4EMAPTHPGDNPC1RAB9A | |
| SCHEMBL12462051 | 0.82 | HPGD (0.57) | KDM4EMAPTHPGDNPC1RAB9A | |
| SCHEMBL883798 | 0.81 | HPGD (0.61) | HPGDNPC1RAB9APYGLFLT1 | |
| SCHEMBL1127878 | 0.81 | KDM4E (1.00) | KDM4EMAPTHPGDNPC1RAB9A | |
| SCHEMBL108531 | 0.81 | CES2 (0.61) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL883797 | 0.81 | NPC1 (0.59) | KDM4EMAPTHPGDNPC1RAB9A | |
| SCHEMBL106341 | 0.80 | HPGD (0.54) | KDM4EHPGDNPC1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL21381943 | 0.79 | KDM4E (0.96) | KDM4EMAPTHPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10851072-B2 | Inhibitors of Rho/MRTF/SRF-mediated gene transcription and methods for use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-12-01 | — | — | US | disclosed |
| US-10851072-B2 | Inhibitors of Rho/MRTF/SRF-mediated gene transcription and methods for use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-12-01 | — | — | US | disclosed |
| WO-2019195641-A2 | INHIBITORS OF RHO/MRTF/SRF-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-10-10 | — | — | WO | disclosed |
| WO-2019195641-A2 | INHIBITORS OF RHO/MRTF/SRF-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-10-10 | — | — | WO | disclosed |
| US-20190308947-A1 | INHIBITORS OF RHO/MRTF/SRF-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2019-10-10 | — | — | US | disclosed |
| US-20190308947-A1 | INHIBITORS OF RHO/MRTF/SRF-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2019-10-10 | — | — | US | disclosed |
| US-20100004221-A1 | THIAZEPINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-01-07 | — | — | US | disclosed |
| EP-2119719-A1 | THIAZEPINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| EP-0368237-B1 | Polymer bound flame retardants | ATOCHEM NORTH AMERICA (US) | 1995-04-12 | — | — | EP | disclosed |
| US-5220015-A | Having hydrazide group to chemically bond to anhydride-containing polymers | ELF ATOCHEM NORTH AMERICA, INC. (US) | 1993-06-15 | — | — | US | disclosed |
| US-5140070-A | Halogenated aromatic compounds having acylamino functional groups bonded to imide containing polymer | ELF ATOCHEM NORTH AMERICA, INC (US) | 1992-08-18 | — | — | US | disclosed |
| US-5077405-A | Condensation of corresponding phenylsulfonyl compound with condensation agent, cyanation, reduction | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-12-31 | — | — | US | disclosed |
| US-5037894-A | Maleic anhydride polymer reacted with halogenated hydrazide compound or derivative | ATOCHEM NORTH AMERICA, INC. (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0417653-A1 | 3-(1-Substituted-4-piperazinyl)-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4954503-A | ANALGESIC, ANTIPSYCHOTIC AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-09-04 | — | — | US | disclosed |
| EP-0368237-A2 | Polymer bound flame retardants | ELF ATOCHEM NORTH AMERICA, INC. (US) | 1990-05-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004221-A1 | THIAZEPINE DERIVATIVE | HSD11B1, HSD17B1, HSD3B1 | KDM4E 3556/4885MAPT 4734/4885HPGD 114/4885 |
| US-20190308947-A1 | INHIBITORS OF RHO/MRTF/SRF-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME | RHOXF2, BPTF, SREBF1 | KDM4E 1414/4885MAPT 3335/4885HPGD 1333/4885 |
| US-10851072-B2 | Inhibitors of Rho/MRTF/SRF-mediated gene transcription and methods for use of the same | RHOXF2, BPTF, SREBF1 | KDM4E 1414/4885MAPT 3335/4885HPGD 1333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.