SCHEMBL3148595

SCHEMBL3148595

Nc1nc2c(ncn2[C@H]2C[C@H](O)[C@@H](COP(N)O)O2)c(=O)[nH]1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.68
P2RY2 P41231 1/20 0.57
P2RY4 P51582 1/20 0.57
P2RY6 Q15077 1/20 0.57
TYMP P19971 1/20 0.51
NT5E P21589 2/20 0.49
HINT1 P49773 1/20 0.49
POLA1 P09884 1/20 0.48
PDE3A Q14432 2/20 0.48
PNP P00491 1/20 0.48
LMNA P02545 1/20 0.48
TP53 P04637 1/20 0.48
HTT P42858 1/20 0.48
PDE4D Q08499 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
RXFP1 Q9HBX9 1/20 0.48
GSK3A P49840 2/20 0.46
RPS6KA3 P51812 2/20 0.46
MAPK14 Q16539 2/20 0.46
STING1 Q86WV6 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9753476 0.92 POLB (0.68) POLBP2RY2P2RY4P2RY6TYMP
SCHEMBL1401380 0.90 POLB (0.56) POLBP2RY2P2RY4P2RY6TYMP
SCHEMBL8490891 0.89 POLB (0.71) POLBP2RY2P2RY4P2RY6TYMP
SCHEMBL442294 0.89 POLB (0.71) POLBP2RY2P2RY4P2RY6TYMP
SCHEMBL338650 0.88 POLB (0.70) POLBP2RY2P2RY4P2RY6TYMP
SCHEMBL16359949 0.88 POLB (0.70) POLBP2RY2P2RY4P2RY6TYMP
SCHEMBL15798769 0.88 POLB (0.70) POLBP2RY2P2RY4P2RY6TYMP
SCHEMBL15012843 0.88 POLB (0.70) POLBP2RY2P2RY4P2RY6TYMP
Deoxyguanosine SCHEMBL3360864 0.88 POLB (0.63) POLBP2RY2P2RY4P2RY6POLA1
SCHEMBL11421357 0.88 POLB (0.67) POLBP2RY2P2RY4P2RY6TYMP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1828218-B1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR GIRINDUS AG (DE) 2014-04-30 EP claimed
US-20130281682-A1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR GIRINDUS AG (DE) 2013-10-24 US claimed
US-20120316328-A1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR GIRINDUS AG (DE) 2012-12-13 US claimed
US-20100081802-A1 Synthesis of Phosphitylated Compounds Using a Quaternary Heterocyclic Activator GIRINDUS AG (DE) 2010-04-01 US claimed
EP-1828218-A1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR Girindus AG (DE) 2007-09-05 EP claimed
WO-2006064039-A1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR GIRINDUS AG (DE) 2006-06-22 WO claimed
US-12406750-B2 Encoding digital data using oligonucleotides LENOVO (SINGAPORE) PTE. LTD. (SG) 2025-09-02 US disclosed
US-20250078958-A1 ENCODING DIGITAL DATA USING OLIGONUCLEOTIDES LENOVO (SINGAPORE) PTE. LTD. (SG) 2025-03-06 US disclosed
US-20240286104-A1 POLYANILINE COATED ELECTRODES FOR POLYMER SYNTHESIS LENOVO (SINGAPORE) PTE. LTD. (SG) 2024-08-29 US disclosed
EP-1828218-B1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR GIRINDUS AG (DE) 2014-04-30 EP disclosed
US-20130281682-A1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR GIRINDUS AG (DE) 2013-10-24 US disclosed
US-20120316328-A1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR GIRINDUS AG (DE) 2012-12-13 US disclosed
US-8247540-B2 Caged nucleotides and oligonucleotides and their application DEITERS ALEXANDER (US) 2012-08-21 US disclosed
US-20010029296-A1 Minimization of blooming in high-density arrays by using reactive wash reagents PERBOST MICHEL G M (US) 2001-10-11 US disclosed
US-6300137-B1 APPLYING CAPPING AGENT TO THE SUBSTRATE TO DEACTIVATE ANY UNREACTED DEPROTECTED BOUND OLIGONUCLEOTIDE, 5'-PROTECTED NUCLEOSIDE PHOSPHORAMIDITES ARE APPLIED IN DROPLETS HAVING COVERING VOLUMES TO FULLY COVER THE FIRST DROPLET; ACCURACY AGILENT TECHNOLOGIES INC. 2001-10-09 US disclosed
US-6184347-B1 Minimization of blooming in high-density arrays by using reactive wash reagents AGILENT TECHNOLOGIES INC. 2001-02-06 US disclosed
EP-0691981-A1 TUMOR TARGETING WITH L-ENANTIOMERIC OLIGONUCLEOTIDE CONJUGATES OF IMMUNOREAGENTS AND OF CHELATED RADIONUCLIDES THE WELLCOME FOUNDATION LIMITED (GB) 1996-01-17 EP disclosed
WO-1994020523-A1 TUMOR TARGETING WITH L-ENANTIOMERIC OLIGONUCLEOTIDE CONJUGATES OF IMMUNOREAGENTS AND OF CHELATED RADIONUCLIDES THE WELLCOME FOUNDATION LIMITED (GB) 1994-09-15 WO disclosed
WO-1989009780-A1 SITE-SPECIFIC TRITIUM-LABELED OLIGODEOXYNUCLEOTIDES CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY (US) 1989-10-19 WO disclosed
WO-1989009778-A1 OLIGONUCLEOTIDE CONTAINING 6-THIOGUANINE AT A PREDETERMINED SITE CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY (US) 1989-10-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240286104-A1 POLYANILINE COATED ELECTRODES FOR POLYMER SYNTHESIS POLRMT, NSUN2, POLI POLB 30/4885P2RY2 4604/4885P2RY4 4071/4885
US-20100081802-A1 Synthesis of Phosphitylated Compounds Using a Quaternary Heterocyclic Activator ARAF, ATIC, PFKFB3 POLB 2894/4885P2RY2 33/4885P2RY4 48/4885
US-20120316328-A1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR ARAF, ATIC, PFKFB3 POLB 3100/4885P2RY2 27/4885P2RY4 41/4885
US-20130281682-A1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR ARAF, ATIC, HK2 POLB 3155/4885P2RY2 37/4885P2RY4 51/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.