SCHEMBL31487835

SCHEMBL31487835

CC(C)(C)OC(=O)N1CCC(c2cnn3cc(C#N)ccc23)CC1

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 14/20 0.53
▸ RET P07949 1/20 0.49
▸ JAK2 O60674 1/20 0.45
▸ JAK3 P52333 1/20 0.45
▸ PTK2 Q05397 1/20 0.45
▸ EGLN2 Q96KS0 1/20 0.44
▸ MEN1 O00255 1/20 0.43
▸ USP2 O75604 1/20 0.43
▸ HPGD P15428 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43
▸ HSD17B10 Q99714 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31487545 0.85 MEN1 (0.45) GPR119RETMEN1USP2HPGD
SCHEMBL31487750 0.84 ALDH1A1 (0.53) GPR119MEN1HPGDKMT2AHSD17B10
SCHEMBL31488149 0.84 MEN1 (0.54) MEN1USP2HPGDKMT2ANPSR1
SCHEMBL31487833 0.83 KMT2A (0.48) GPR119MEN1USP2HPGDKMT2A
SCHEMBL31488117 0.83 MEN1 (0.44) GPR119RETMEN1USP2HPGD
SCHEMBL31487901 0.82 GPR119 (0.52) GPR119MEN1USP2HPGDKMT2A
SCHEMBL31487870 0.82 GPR119 (0.48) GPR119RETMEN1USP2HPGD
SCHEMBL31487926 0.81 MAPT (0.50) GPR119MEN1USP2HPGDKMT2A
SCHEMBL31488038 0.80 RET (0.59) GPR119RETMEN1HPGDKMT2A
SCHEMBL31487885 0.80 GPR119 (0.46) GPR119RETMEN1USP2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025089370-A1 COMPOUNDS AS CSF1R INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2025-05-01 — — WO disclosed
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