Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27967611 | 0.77 | DPP4 (0.40) | MEN1KMT2ASMN1; SMN2HTR7DPP4 | |
| SCHEMBL4687606 | 0.73 | PTGS2 (0.32) | PTGS2 | |
| SCHEMBL695988 | 0.72 | PDCD1 (0.39) | MEN1KMT2ASMN1; SMN2DPP4ALDH1A1 | |
| SCHEMBL3539990 | 0.72 | ALDH1A1 (0.35) | MEN1KMT2ASMN1; SMN2HTR7DPP4 | |
| SCHEMBL9297636 | 0.72 | DDB1 (0.32) | MEN1KMT2AALDH1A1MAPK1MAPT | |
| SCHEMBL6638777 | 0.72 | TAAR1 (0.44) | MEN1KMT2ASMN1; SMN2HTR7DPP4 | |
| SCHEMBL7487017 | 0.71 | PGR (0.39) | MEN1KMT2ASMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL11473400 | 0.71 | ALDH1A1 (0.46) | MEN1KMT2ASMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL13736563 | 0.71 | NOTUM (0.37) | ALDH1A1HSD17B10MAPK1KDM4E | |
| SCHEMBL11661579 | 0.71 | HTR1A (0.38) | MEN1KMT2ASMN1; SMN2HTR7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021064188-A1 | COMBINATION COMPRISING HDAC INHIBITOR, CTLA-4 INHIBITOR AND A PD-1 INHIBITOR OR PD-L1 INHIBITOR FOR CANCER TREATMENT | 4SC AG (DE) | 2021-04-08 | — | — | WO | disclosed |
| EP-3781159-A1 | COMBINATION COMPRISING HDAC INHIBITOR, LAG-3 INHIBITOR AND A PD-1 INHIBITOR OR PD-L1 INHIBITOR FOR CANCER TREATMENT | 4SC AG (DE) | 2021-02-24 | — | — | EP | disclosed |
| EP-3773554-A1 | COMBINATION COMPRISING HDAC INHIBITOR AND CD137 AGONIST FOR CANCER THERAPY | 4SC AG (DE) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019202001-A1 | COMBINATION COMPRISING HDAC INHIBITOR, LAG-3 INHIBITOR AND A PD-1 INHIBITOR OR PD-L1 INHIBITOR FOR CANCER TREATMENT | 4SC AG (DE) | 2019-10-24 | — | — | WO | disclosed |
| WO-2019185598-A1 | COMBINATION COMPRISING HDAC INHIBITOR AND CD137 AGONIST FOR CANCER THERAPY | 4SC AG (DE) | 2019-10-03 | — | — | WO | disclosed |
| US-8815855-B2 | N-sulphonylpyrroles and their use as histone deacetylase inhibitors | 4SC AG (DE) | 2014-08-26 | — | — | US | disclosed |
| CN-1762957-B | 2,3-dihydro-1-indene compound and preparation method thereof | BASELL POLYOLEFINE GMBH | 2010-05-12 | — | — | CN | disclosed |
| US-20100074862-A1 | N-SULPHONYLPYRROLES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | MAIER THOMAS | 2010-03-25 | — | — | US | disclosed |
| CN-100451024-C | Metallocene compound, indene compound and application thereof | BASELL POLYOLEFINE GMBH (DE) | 2009-01-14 | — | — | CN | disclosed |
| CN-1763060-A | Metallocene compound, indene compound and application thereof | BASELL POLYOLEFINE GMBH (DE) | 2006-04-26 | — | — | CN | disclosed |
| CN-1762957-A | 2,3-dihydro-1-indene compound and preparation method thereof | BASELL POLYOLEFINE GMBH (DE) | 2006-04-26 | — | — | CN | disclosed |
| CN-1231431-C | Process for preparing substituted 2, 3-dihydro-1-indanones | TARGOR GMBH (DE) | 2005-12-14 | — | — | CN | disclosed |
| EP-1066268-A1 | 5-SUBSTITUTED PYRIMIDINE-2-YLOXY CARBOXYLIC ACID DERIVATIVES, THE PRODUCTION OF THE SAME AND THEIR UTILIZATION AS ENDOTHELIN ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 2001-01-10 | — | — | EP | disclosed |
| CN-1254328-A | Process for preparing substituted 2, 3-dihydro-1-indanones | TARGOR GMBH (DE) | 2000-05-24 | — | — | CN | disclosed |
| WO-1999042453-A1 | 5-SUBSTITUTED PYRIMIDINE-2-YLOXY CARBOXYLIC ACID DERIVATIVES, THE PRODUCTION OF THE SAME AND THEIR UTILIZATION AS ENDOTHELIN ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 1999-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100074862-A1 | N-SULPHONYLPYRROLES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC3, HDAC2 | MEN1 4245/4885KMT2A 74/4885SMN1; SMN2 2017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.