Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 7/20 | 0.44 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5536178 | 0.95 | TDP1 (0.46) | TDP1LTA4H | |
| SCHEMBL3163550 | 0.83 | LTA4H (0.48) | LTA4H | |
| SCHEMBL3160187 | 0.82 | SLC6A2 (0.42) | VCP | |
| SCHEMBL5545285 | 0.78 | TDP1 (0.47) | TDP1 | |
| SCHEMBL4178227 | 0.77 | CHRNB2 (0.34) | LTA4H | |
| SCHEMBL5535778 | 0.74 | GRIN2B (0.40) | LTA4H | |
| SCHEMBL10533845 | 0.74 | PARP15 (0.56) | TDP1LTA4H | |
| SCHEMBL2200352 | 0.73 | TDP1 (0.50) | TDP1 | |
| SCHEMBL42737 | 0.73 | NOS3 (0.53) | — | |
| SCHEMBL8356592 | 0.72 | PARP15 (0.57) | TDP1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0577470-B1 | 2-Amino-N-[[[4-(aminocarbonyl)pyrimidin-2-yl]amino]alkyl]-pyrimidine-4-carboxamide derivates, their preparation and their use in therapeutics | SYNTHELABO (FR) | 1995-05-24 | — | — | EP | claimed |
| US-5330985-A | Adrenergic blocking agents; urogenital disorders | SYNTHELABO (FR) | 1994-07-19 | — | — | US | claimed |
| US-8741934-B2 | Inhibitors of ion channels | PFIZER LIMITED (GB) | 2014-06-03 | — | — | US | disclosed |
| US-20130072471-A1 | Inhibitors of Ion Channels | MARRON BRIAN EDWARD (US) | 2013-03-21 | — | — | US | disclosed |
| US-8357711-B2 | Heterocyclic sulfonamides as inhibitors of ion channels | PFIZER LIMITED (GB) | 2013-01-22 | — | — | US | disclosed |
| EP-1995241-B1 | Inhibitors of ion channels | ICAGEN INC (US) | 2010-03-17 | — | — | EP | disclosed |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2009-06-04 | — | — | US | disclosed |
| EP-1995241-A1 | Inhibitors of ion channels | ICAgen, Incorporated (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2008118758-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (GB) | 2008-10-02 | — | — | WO | disclosed |
| CN-1100416-A | Derivative of 2-amino-N-{{{4-(aminocarbonyl)pyrimidin-2-yl}amizo}alkyl}pyrimidiny-4-carboxamide, preparation and pharmaceutical application of same | SYNTHELABO (FR) | 1995-03-22 | — | — | CN | disclosed |
| US-5330985-A | Adrenergic blocking agents; urogenital disorders | SYNTHELABO (FR) | 1994-07-19 | — | — | US | disclosed |
| US-5330985-A | Adrenergic blocking agents; urogenital disorders | SYNTHELABO (FR) | 1994-07-19 | — | — | US | disclosed |
| EP-0577470-A1 | 2-Amino-N-[[[4-(aminocarbonyl)pyrimidin-2-yl]amino]alkyl]-pyrimidine-4-carboxamide derivates, their preparation and their use in therapeutics | SYNTHELABO (FR) | 1994-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072471-A1 | Inhibitors of Ion Channels | TRPV1, TRPV5, TRPA1 | TDP1 4420/4885LTA4H 586/4885VCP 793/4885 |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPV5, TRPA1 | TDP1 4420/4885LTA4H 586/4885VCP 793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.