Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMD14 | O00487 | 2/20 | 0.56 |
| ▸ | COPS5 | Q92905 | 2/20 | 0.56 |
| ▸ | CCR1 | P32246 | 3/20 | 0.53 |
| ▸ | CCR8 | P51685 | 3/20 | 0.53 |
| ▸ | CCR5 | P51681 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3142508 | 0.86 | PSMD14 (0.56) | PSMD14COPS5CCR1CCR8CCR5 | |
| SCHEMBL23832886 | 0.83 | HTT (0.46) | HTTPTGDR2ARALDH1A1LRRK2 | |
| SCHEMBL10008410 | 0.79 | NR4A2 (0.56) | TSHRHTTPTGDR2ARALDH1A1 | |
| SCHEMBL4012471 | 0.79 | KDM4E (0.42) | L3MBTL1TSHRHTTPTGDR2AR | |
| SCHEMBL5759312 | 0.79 | HTR1A (0.51) | PSMD14COPS5CCR1CCR8CCR5 | |
| SCHEMBL317372 | 0.79 | KDM4E (0.49) | CCR1CCR8L3MBTL1HTTSLC6A2 | |
| SCHEMBL667933 | 0.79 | HTT (0.42) | HTTPTGDR2ARALDH1A1HSP90AA1 | |
| SCHEMBL18368395 | 0.78 | ALDH1A1 (0.38) | PSMD14COPS5HTTPTGDR2AR | |
| SCHEMBL16132482 | 0.77 | CCR1 (0.55) | CCR1CCR8CCR5L3MBTL1TSHR | |
| SCHEMBL2607397 | 0.77 | PSMD14 (0.68) | PSMD14COPS5CCR1CCR8CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170008905-A1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. | 2017-01-12 | — | — | US | disclosed |
| EP-2233493-A1 | Macrolides | Pfizer Products Inc. (US) | 2010-09-29 | — | — | EP | disclosed |
| EP-1836211-B1 | MACROLIDES | PFIZER PROD INC (US) | 2010-03-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170008905-A1 | COT MODULATORS AND METHODS OF USE THEREOF | BRDT, THRB, HCCS | PSMD14 3798/4885COPS5 2234/4885CCR1 3493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.