Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.72 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | EBP | Q15125 | 3/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.48 |
| ▸ | EBPL | Q9BY08 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30623414 | 0.86 | SIGMAR1 (0.56) | SIGMAR1OPRM1OPRK1OPRD1ADRA2A | |
| SCHEMBL25359123 | 0.86 | SIGMAR1 (0.56) | SIGMAR1OPRM1OPRK1OPRD1ADRA2A | |
| SCHEMBL25357939 | 0.84 | SIGMAR1 (1.00) | SIGMAR1OPRM1OPRK1OPRD1ADRA2A | |
| SCHEMBL26013277 | 0.70 | SIGMAR1 (0.41) | SIGMAR1OPRM1OPRK1OPRD1ADRA2A | |
| SCHEMBL26012638 | 0.69 | SIGMAR1 (0.56) | SIGMAR1 | |
| SCHEMBL25355453 | 0.69 | SIGMAR1 (0.59) | SIGMAR1 | |
| SCHEMBL26012503 | 0.69 | SIGMAR1 (0.59) | SIGMAR1 | |
| SCHEMBL11684907 | 0.68 | SIGMAR1 (0.70) | SIGMAR1OPRM1OPRK1OPRD1ADRA2A | |
| SCHEMBL25358567 | 0.67 | SIGMAR1 (0.54) | SIGMAR1 | |
| SCHEMBL26012637 | 0.67 | SIGMAR1 (0.54) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250195483-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMA (US) | 2025-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250195483-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | APOL1, PNLIP, SAAL1 | SIGMAR1 790/4885OPRM1 1003/4885OPRK1 639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.