Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.37 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.36 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 5/20 | 0.37 |
| ▸ | HTR1B | P28222 | 5/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL31636001 | 0.98 | HTR1A (0.39) | SMYD2HTR1ASLC6A4HTR1DHTR1B | |
| SCHEMBL31635986 | 0.90 | MPO (0.44) | HTR1AMPOSLC6A4HTR1DHTR1B | |
| SCHEMBL31326313 | 0.88 | HTR2A (0.45) | HTR1AMPOSLC6A4HTR1DHTR1B | |
| Fumaric Acid SCHEMBL31635960 | 0.84 | MPO (0.40) | HTR1AMPOHTR1DHTR1B | |
| Fumaric Acid SCHEMBL31635973 | 0.82 | HTR2A (0.40) | HTR1AMPOHTR1DHTR1B | |
| Fumaric Acid SCHEMBL31635972 | 0.78 | HTR2A (0.41) | HTR1ASLC6A4HTR1DHTR1BHTR6 | |
| Fumaric Acid SCHEMBL31635979 | 0.77 | HTR1A (0.39) | HTR1ASLC6A4HTR1BHTR6 | |
| Fumaric Acid SCHEMBL31635982 | 0.77 | HTR1B (0.40) | HTR1ASLC6A4HTR1DHTR1BHTR6 | |
| SCHEMBL31326340 | 0.73 | MPO (0.47) | HTR1AMPOHTR1DHTR1B | |
| SCHEMBL31326367 | 0.73 | MPO (0.60) | HTR1AMPOHTR1DHTR1BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250361233-A1 | Compounds For Activating Serotonin Receptor | Psylo Pty Ltd (AU) | 2025-11-27 | — | — | US | disclosed |
| US-12415804-B2 | Compounds for activating a serotonin receptor | Psylo Pty Ltd (AU) | 2025-09-16 | — | — | US | disclosed |
| US-20250206739-A1 | Compounds | Psylo Pty Ltd (AU) | 2025-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250206739-A1 | Compounds | NLN, SLC18A2, PYGB | SLC6A4 18/4885KCNH2 2136/4885SMYD2 3547/4885 |
| US-12415804-B2 | Compounds for activating a serotonin receptor | HTR2C, HTR6, HTR2A | SLC6A4 21/4885KCNH2 2991/4885SMYD2 4227/4885 |
| US-20250361233-A1 | Compounds For Activating Serotonin Receptor | HTR2C, HTR2A, HTR6 | SLC6A4 20/4885KCNH2 2865/4885SMYD2 4219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.