Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | PRKDC | P78527 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ERN1 | O75460 | 6/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.43 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.41 |
| ▸ | ABAT | P80404 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31549326 | 0.81 | CASP6 (0.59) | ALDH1A1CYP3A4MAPTHSD17B10CASP6 | |
| SCHEMBL11203665 | 0.81 | CASP6 (0.59) | ALDH1A1CYP3A4MAPTHSD17B10CASP6 | |
| SCHEMBL9215364 | 0.79 | ALDH1A1 (0.62) | ALDH1A1CYP3A4MAPTKDM4EALOX15 | |
| SCHEMBL11268929 | 0.79 | ALDH1A1 (0.49) | ALDH1A1CYP3A4MAPTKDM4EALOX15 | |
| SCHEMBL3164630 | 0.79 | ERN1 (0.48) | ALDH1A1CYP3A4MAPTKDM4EALOX15 | |
| SCHEMBL3173935 | 0.79 | ALDH1A1 (0.50) | ALDH1A1CYP3A4MAPTKDM4EALOX15 | |
| SCHEMBL9763412 | 0.77 | ALDH1A1 (0.55) | ALDH1A1CYP3A4MAPTKDM4EALOX15 | |
| SCHEMBL13524148 | 0.76 | MAPT (0.67) | ALDH1A1MAPTKDM4ECASP6MEN1 | |
| SCHEMBL29364404 | 0.76 | LMNA (0.58) | ALDH1A1ERN1TSHRTDP1MEN1 | |
| SCHEMBL652955 | 0.76 | LMNA (0.58) | ALDH1A1ERN1TSHRTDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140050778-A1 | NUCLEIC ACID BINDING COMPOUNDS, METHODS OF MAKING, AND USE THEREOF | UNIVERSITY OF ROCHESTER (US) | 2014-02-20 | — | — | US | disclosed |
| WO-2012092367-A1 | NUCLEIC ACID BINDING COMPOUNDS, METHODS OF MAKING, AND USE THEREOF | UNIVERSITY OF ROCHESTER (US) | 2012-07-05 | — | — | WO | disclosed |
| US-20110028350-A1 | PHOTOCLEAVABLE PROTECTING GROUPS | AFFYMETRIX, INC. (US) | 2011-02-03 | — | — | US | disclosed |
| US-20100324266-A1 | Photocleavable Protecting Groups | AFFYMETRIX, INC. (US) | 2010-12-23 | — | — | US | disclosed |
| US-7645760-B2 | 1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives | NOVARTIS AG. (CH) | 2010-01-12 | — | — | US | disclosed |
| US-7645760-B2 | 1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives | NOVARTIS AG. (CH) | 2010-01-12 | — | — | US | disclosed |
| CN-101570517-A | 1- (4-benzyl-piperazin-1-yl) -3-phenyl-propenone derivatives | NOVARTIS AG (CH) | 2009-11-04 | — | — | CN | disclosed |
| CN-100554257-C | 1- (4-benzyl-piperazin-1-yl) -3-phenyl-propenone derivatives | NOVARTIS AG (CH) | 2009-10-28 | — | — | CN | disclosed |
| US-20090076295-A1 | PHOTOCLEAVABLE PROTECTING GROUPS | AFFYMETRIX, INC. (US) | 2009-03-19 | — | — | US | disclosed |
| US-20060173004-A1 | 1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives | NOVARTIS AG (CH) | 2006-08-03 | — | — | US | disclosed |
| CN-1708489-A | 1- (4-benzyl-piperazin-1-yl) -3-phenyl-propenone derivatives | NOVARTIS AG (CH) | 2005-12-14 | — | — | CN | disclosed |
| EP-1558594-A2 | 1-(4-BENZYL-PIPERAZIN-1-YL)-3-PHENYL-PROPENONE DERIVATIVES | Novartis AG (CH) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004037796-A2 | 1-(4-BENZYL-PIPERAZIN-1-YL)-3-PHENYL-PROPENONE DERIVATIVES | NOVARTIS AG (CH) | 2004-05-06 | — | — | WO | disclosed |
| US-6329546-B1 | FOR INVESTIGATING THE MECHANISM OF ACTION OF A PHYSIOLOGICALLY ACTIVE AMINO ACID COMPOUND SUCH AS GLUTAMIC ACID IN AN ORGANISM | LABORATORY OF MOLECULAR BIOPHOTONICS (JP) | 2001-12-11 | — | — | US | disclosed |
| US-6229020-B1 | REACTING N-SUCCINIMIDYL AND P-NITROPHENYL CINNAMATE DERIVATIVES WITH PHYSIOLOGICALLY ACTIVE SUBSTANCE SUCH AS AN AMINO ACID; PROTECTING AMINO OR HYDROXY GROUPS FOR ANALYSIS OF BIOLOGICAL REACTIONS BY IRRADIATION WITH LIGHT | LABORATORY OF MOLECULAR BIOPHOTONICS (JP) | 2001-05-08 | — | — | US | disclosed |
| EP-0199153-B1 | LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-11-07 | — | — | EP | disclosed |
| US-4933355-A | ALDOSE REDUCTASE INHIBITORS | SANKYO COMPANY LIMITED (JP) | 1990-06-12 | — | — | US | disclosed |
| EP-0337819-A1 | Thiazole derivatives, their preparation and their use in the treatment of diabetes complications | Sankyo Company Limited (JP) | 1989-10-18 | — | — | EP | disclosed |
| EP-0199153-A2 | Lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1986-10-29 | — | — | EP | disclosed |
| US-4608390-A | ANTIINFLAMMORY, ANTIALLERGENS, ASTHMA, PSORIASIS, ARTHRITIS | ABBOTT LABORATORIES (US) | 1986-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140050778-A1 | NUCLEIC ACID BINDING COMPOUNDS, METHODS OF MAKING, AND USE THEREOF | NSUN3, NSUN2, HNRNPF | ALDH1A1 1547/4885CYP3A4 4031/4885MAPT 2994/4885 |
| US-20100324266-A1 | Photocleavable Protecting Groups | POLL, PCNA, ERCC4 | ALDH1A1 1340/4885CYP3A4 3603/4885MAPT 2839/4885 |
| US-20060173004-A1 | 1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives | CCR1, CCR3, CCR4 | ALDH1A1 290/4885CYP3A4 1170/4885MAPT 2279/4885 |
| US-20090076295-A1 | PHOTOCLEAVABLE PROTECTING GROUPS | POLL, PCNA, ERCC4 | ALDH1A1 1340/4885CYP3A4 3603/4885MAPT 2839/4885 |
| US-20110028350-A1 | PHOTOCLEAVABLE PROTECTING GROUPS | POLL, ERCC5, FBL | ALDH1A1 2363/4885CYP3A4 3236/4885MAPT 2833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.