Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31649065 | 0.83 | TACR1 (0.39) | NPC1RAB9ASMN1; SMN2DPP4FAP | |
| SCHEMBL31649010 | 0.82 | HSD11B1 (0.38) | NPC1RAB9ASMN1; SMN2HSD11B1HSD17B1 | |
| SCHEMBL31649284 | 0.82 | HSD11B1 (0.39) | DPP4DPP8HSD11B1POLBTDP1 | |
| SCHEMBL31649243 | 0.80 | KMT2A (0.41) | SMN1; SMN2POLBTDP1TACR1MAPT | |
| SCHEMBL31649455 | 0.80 | KMT2A (0.41) | SMN1; SMN2POLBTDP1TACR1MAPT | |
| SCHEMBL31649089 | 0.80 | DPP4 (0.41) | DPP4FAPDPP8DPP9HSD11B1 | |
| SCHEMBL31649051 | 0.79 | HTR2A (0.40) | POLB | |
| SCHEMBL31649016 | 0.79 | HRH3 (0.36) | DPP4HSD11B1MAPT | |
| SCHEMBL31649005 | 0.72 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBTDP1TACR1 | |
| SCHEMBL19002341 | 0.71 | SMN1; SMN2 (0.49) | NPC1RAB9ASMN1; SMN2DPP4FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025132943-A1 | DECAHYDROQUINOLINES AS DNA POLYMERASE THETA INHIBITORS | BREAKPOINT THERAPEUTICS GMBH (DE) | 2025-06-26 | — | — | WO | claimed |
| WO-2025132943-A1 | DECAHYDROQUINOLINES AS DNA POLYMERASE THETA INHIBITORS | BREAKPOINT THERAPEUTICS GMBH (DE) | 2025-06-26 | — | — | WO | disclosed |