Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | ACACB | O00763 | 4/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31649089 | 0.91 | DPP4 (0.41) | HRH3HSD11B1DPP4ALDH1A1 | |
| SCHEMBL31649010 | 0.88 | HSD11B1 (0.38) | HSD11B1ALDH1A1MEN1KMT2ADRD2 | |
| SCHEMBL31649409 | 0.84 | RORC (0.40) | HRH3HSD11B1FAAHMEN1KMT2A | |
| SCHEMBL31649339 | 0.80 | DPP4 (0.42) | HRH3HSD11B1DPP4ALDH1A1DRD2 | |
| SCHEMBL31649243 | 0.80 | KMT2A (0.41) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL31649455 | 0.80 | KMT2A (0.41) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL31649051 | 0.79 | HTR2A (0.40) | ALDH1A1MEN1KMT2A | |
| SCHEMBL31649304 | 0.79 | NPC1 (0.39) | HSD11B1DPP4MAPT | |
| SCHEMBL31649284 | 0.76 | HSD11B1 (0.39) | HSD11B1DPP4ALDH1A1 | |
| SCHEMBL31649254 | 0.74 | DRD2 (0.49) | HSD11B1DPP4DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025132943-A1 | DECAHYDROQUINOLINES AS DNA POLYMERASE THETA INHIBITORS | BREAKPOINT THERAPEUTICS GMBH (DE) | 2025-06-26 | — | — | WO | claimed |
| WO-2025132943-A1 | DECAHYDROQUINOLINES AS DNA POLYMERASE THETA INHIBITORS | BREAKPOINT THERAPEUTICS GMBH (DE) | 2025-06-26 | — | — | WO | disclosed |