Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31649089 | 0.89 | DPP4 (0.41) | HSD11B1UBE2MDCUN1D1ALDH1A1CCR1 | |
| SCHEMBL31649016 | 0.88 | HRH3 (0.36) | HSD11B1DRD2DRD4ALDH1A1MEN1 | |
| SCHEMBL31649221 | 0.83 | HSD11B1 (0.40) | HSD11B1DRD2DRD4SMN1; SMN2NPC1 | |
| SCHEMBL31649304 | 0.82 | NPC1 (0.39) | HSD11B1SMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL31649284 | 0.80 | HSD11B1 (0.39) | HSD11B1POLBTDP1ALDH1A1 | |
| SCHEMBL31649339 | 0.78 | DPP4 (0.42) | HSD11B1DRD2DRD4ALDH1A1CCR1 | |
| SCHEMBL31649243 | 0.78 | KMT2A (0.41) | SMN1; SMN2POLBTDP1ALDH1A1MEN1 | |
| SCHEMBL31649455 | 0.78 | KMT2A (0.41) | SMN1; SMN2POLBTDP1ALDH1A1MEN1 | |
| SCHEMBL31649254 | 0.78 | DRD2 (0.49) | HSD11B1DRD2DRD4CCR1 | |
| SCHEMBL31649236 | 0.76 | DRD2 (0.47) | HSD11B1DRD2DRD4CYP2D6CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025132943-A1 | DECAHYDROQUINOLINES AS DNA POLYMERASE THETA INHIBITORS | BREAKPOINT THERAPEUTICS GMBH (DE) | 2025-06-26 | — | — | WO | claimed |
| WO-2025132943-A1 | DECAHYDROQUINOLINES AS DNA POLYMERASE THETA INHIBITORS | BREAKPOINT THERAPEUTICS GMBH (DE) | 2025-06-26 | — | — | WO | disclosed |