SCHEMBL31661330

SCHEMBL31661330

C=Cc1cc2c3ncc(C#N)c(Cl)c3n(CC(F)(F)F)c2cn1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
METAP2 P50579 3/20 0.33
PDE9A O76083 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31661323 0.90 METAP2 (0.35) METAP2
SCHEMBL31661359 0.84 METAP2 (0.35) METAP2
SCHEMBL31661090 0.79 METAP2 (0.31) METAP2
SCHEMBL31661349 0.79 METAP2 (0.36) METAP2
SCHEMBL31661369 0.78 PTGER4 (0.37) METAP2
SCHEMBL31661387 0.75 MELK (0.35) METAP2
SCHEMBL31661379 0.74 RET (0.32) METAP2
SCHEMBL31661374 0.71 CHKA (0.41)
SCHEMBL31661077 0.69 DYRK3 (0.38)
SCHEMBL31661080 0.68 METAP2 (0.32) METAP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025151549-A1 PYRIDO[3,2-B]INDOLE-3-CARBONITRILE COMPOUNDS AND COMPOSITION FOR TARGETING TP53-Y220C MUTANTS FLARE THERAPEUTICS INC. (US) 2025-07-17 WO disclosed