Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 3/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31662101 | 0.92 | MAPT (0.38) | NTRK1KCNH2NTRK2SCN9APOLB | |
| SCHEMBL31661960 | 0.92 | SCN1A (0.37) | CHEK2SCN9ADRD4TMEM97SIGMAR1 | |
| SCHEMBL31662113 | 0.92 | SCN9A (0.39) | IRAK4SCN9ADRD4TMEM97SIGMAR1 | |
| SCHEMBL31662291 | 0.92 | NTRK1 (0.38) | IRAK4NTRK1KCNH2NTRK2SCN9A | |
| SCHEMBL31661958 | 0.91 | LTA4H (0.36) | CHEK2IRAK4CYP11B2SCN9ADRD3 | |
| SCHEMBL31661890 | 0.90 | NTRK1 (0.37) | NTRK1KCNH2NTRK2SCN9APOLB | |
| SCHEMBL31662561 | 0.89 | CHEK2 (0.44) | CHEK2PARP1 | |
| SCHEMBL31661875 | 0.88 | SCN9A (0.40) | CHEK2IRAK4SCN9A | |
| SCHEMBL31662165 | 0.88 | IRAK4 (0.37) | IRAK4NTRK1SCN9AJAK2JAK3 | |
| SCHEMBL31661999 | 0.87 | SCN9A (0.36) | IRAK4SCN9ADRD4TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025149545-A1 | HETEROARYLPHENYL ETHER DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2025-07-17 | — | — | WO | claimed |
| WO-2025149545-A1 | HETEROARYLPHENYL ETHER DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2025-07-17 | — | — | WO | disclosed |