Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 6/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31661890 | 0.94 | NTRK1 (0.37) | NTRK1KCNH2NTRK2KDM1ANTRK3 | |
| SCHEMBL31661864 | 0.92 | SCN9A (0.34) | NTRK1KCNH2NTRK2KDM1ASCN9A | |
| SCHEMBL31661986 | 0.92 | CHEK2 (0.40) | NTRK1KCNH2NTRK2NTRK3SCN9A | |
| SCHEMBL31662101 | 0.91 | MAPT (0.38) | NTRK1KCNH2NTRK2KDM1ASCN9A | |
| SCHEMBL31661960 | 0.91 | SCN1A (0.37) | SCN9ADRD4SIGMAR1TMEM97ALDH1A1 | |
| SCHEMBL31662113 | 0.90 | SCN9A (0.39) | SCN9ADRD4SIGMAR1TMEM97IRAK4 | |
| SCHEMBL31662561 | 0.88 | CHEK2 (0.44) | — | |
| SCHEMBL31661875 | 0.86 | SCN9A (0.40) | KDM1ASCN9AIRAK4 | |
| SCHEMBL31662165 | 0.86 | IRAK4 (0.37) | NTRK1TBK1SCN9AIRAK4 | |
| SCHEMBL31661999 | 0.85 | SCN9A (0.36) | SCN9ADRD4SIGMAR1TMEM97IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025149545-A1 | HETEROARYLPHENYL ETHER DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2025-07-17 | — | — | WO | claimed |
| WO-2025149545-A1 | HETEROARYLPHENYL ETHER DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2025-07-17 | — | — | WO | disclosed |