SCHEMBL31662836

SCHEMBL31662836

CNc1ccc(CN2C(=O)C(Cl)=C(Cl)C2O)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.36
HKDC1 Q2TB90 1/20 0.36
HPGD P15428 3/20 0.33
LMNA P02545 1/20 0.33
ALDH1A1 P00352 4/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC11 Q96DB2 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
TP53 P04637 2/20 0.31
CYP3A4 P08684 2/20 0.31
THRB P10828 1/20 0.31
ALOX15 P16050 1/20 0.31
CASP1 P29466 1/20 0.31
RECQL P46063 1/20 0.31
HIF1A Q16665 1/20 0.31
HSD17B10 Q99714 1/20 0.31
MDM2 Q00987 1/20 0.31
MAPT P10636 4/20 0.31
CYP1A2 P05177 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31662697 0.85 BRD4 (0.38) KDM4EHKDC1HPGDLMNAALDH1A1
SCHEMBL31662909 0.85 ALDH1A1 (0.48) KDM4EALDH1A1HDAC1HDAC11HDAC8
SCHEMBL24624434 0.83 MAPT (0.42) KDM4EHKDC1LMNAALDH1A1TP53
SCHEMBL24624436 0.81 CAPN1 (0.37) KDM4EHKDC1HPGDLMNATP53
SCHEMBL31662790 0.80 LMNA (0.38) KDM4EHKDC1HPGDLMNAALDH1A1
SCHEMBL31662651 0.80 CA1 (0.40) LMNAALDH1A1MAPTKMT2AMEN1
SCHEMBL17987976 0.80 KMT2A (0.47) KDM4EHPGDLMNAALDH1A1TP53
SCHEMBL31662937 0.79 ALDH1A1 (0.40) KDM4EHKDC1HPGDALDH1A1HDAC1
SCHEMBL31662812 0.79 PTGDR2 (0.46) HDAC8
SCHEMBL31662895 0.78 PTGS1 (0.47) KDM4EALDH1A1THRBRECQLHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025147756-A1 VIRAL SENSITIZERS COMPOSITIONS, METHODS AND USES THEREOF OTTAWA HOSPITAL RESEARCH INSTITUTE (CA) 2025-07-17 WO disclosed