Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29502570 | 0.88 | AGBL2 (0.43) | KIF11RXRARXRBRXRGTRPM8 | |
| SCHEMBL30767641 | 0.85 | SMN1; SMN2 (0.40) | TRPA1ALDH1A1KDM4ESMN1; SMN2POLB | |
| SCHEMBL12970141 | 0.80 | MAP2K4 (0.47) | KIF11MAP2K4FYNPOLBEP300 | |
| SCHEMBL10762792 | 0.77 | JAK3 (0.49) | TRPA1ALDH1A1KDM4ESMN1; SMN2POLB | |
| SCHEMBL2269528 | 0.73 | KIF11 (0.51) | KIF11FYN | |
| SCHEMBL18975045 | 0.72 | AGBL2 (0.47) | ALDH1A1AGBL2RAB9AHTTGAA | |
| SCHEMBL1781036 | 0.70 | KIF11 (0.58) | KIF11RXRARXRBRXRGPSEN1 | |
| SCHEMBL13267997 | 0.70 | RXRA (0.64) | KIF11RXRARXRBRXRGPSEN1 | |
| SCHEMBL31521744 | 0.69 | MKNK1 (0.47) | KIF11MAP2K4FYNALDH1A1KDM4E | |
| SCHEMBL27174522 | 0.69 | MKNK1 (0.47) | KIF11MAP2K4FYNALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4568960-B1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2026-04-29 | — | — | EP | disclosed |
| US-20250236614-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2025-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250236614-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES | GRIN2C, CNR1, CNR2 | KIF11 2058/4885TRPA1 469/4885RXRA 1487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.