Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.59 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 2/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30946928 | 0.88 | CA12 (0.69) | APAF1ATMSAE1UBA2CA12 | |
| SCHEMBL9333914 | 0.88 | CA12 (0.69) | APAF1ATMSAE1UBA2CA12 | |
| Nitric Acid SCHEMBL4371650 | 0.84 | CA12 (0.73) | APAF1ATMSAE1UBA2CA12 | |
| Nitric Acid SCHEMBL5580973 | 0.84 | CA12 (0.73) | APAF1ATMSAE1UBA2CA12 | |
| SCHEMBL3043845 | 0.83 | ALDH1A1 (0.51) | APAF1ATMSAE1UBA2CA12 | |
| SCHEMBL12416827 | 0.81 | APAF1 (0.52) | APAF1ATMSAE1UBA2CA12 | |
| SCHEMBL27930462 | 0.81 | ALDH1A1 (0.66) | APAF1ATMSAE1UBA2CA12 | |
| SCHEMBL21747488 | 0.81 | MAPT (0.49) | APAF1ATMSAE1UBA2MAPT | |
| SCHEMBL21747489 | 0.81 | MAPT (0.49) | APAF1ATMSAE1UBA2MAPT | |
| SCHEMBL10090684 | 0.80 | ALDH1A1 (0.62) | APAF1ATMSAE1UBA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104651476-B | Novel nitroreductase substrates | 生物梅里埃公司 | 2020-02-18 | — | — | CN | disclosed |
| EP-2479282-B1 | Media including nitroreductase enzymatic substrates | BIOMERIEUX SA (FR) | 2018-03-28 | — | — | EP | disclosed |
| CN-104531832-B | Novel nitroreductase enzymatic substrates | 生物梅里埃公司 | 2017-10-27 | — | — | CN | disclosed |
| EP-2155893-B1 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | BIOMERIEUX SA (FR) | 2016-10-19 | — | — | EP | disclosed |
| EP-2471944-B1 | Novel peptidase substrates | BIOMERIEUX SA (FR) | 2016-09-14 | — | — | EP | disclosed |
| EP-2155892-B1 | NOVEL PEPTIDASE SUBSTRATES | BIOMERIEUX SA (FR) | 2015-03-18 | — | — | EP | disclosed |
| EP-2479282-A1 | Media including nitroreductase enzymatic substrates | bioMérieux (FR) | 2012-07-25 | — | — | EP | disclosed |
| US-8216800-B2 | Substrates for detecting peptidase activity and methods using the substrates | BIOMERIEUX (FR) | 2012-07-10 | — | — | US | disclosed |
| EP-2471944-A1 | Novel peptidase substrates | bioMérieux (FR) | 2012-07-04 | — | — | EP | disclosed |
| US-8211662-B2 | Nitroreductase enzymatic substrates | BIOMERIEUX (FR) | 2012-07-03 | — | — | US | disclosed |
| US-20100221764-A1 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | BIOMERIEUX (FR) | 2010-09-02 | — | — | US | disclosed |
| US-20100099128-A1 | NOVEL PEPTIDASE SUBSTRATES | BIOMERIEUX (FR) | 2010-04-22 | — | — | US | disclosed |
| EP-2155892-A2 | NOVEL PEPTIDASE SUBSTRATES | BIOMERIEUX (FR) | 2010-02-24 | — | — | EP | disclosed |
| EP-2155893-A2 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | BIOMERIEUX (FR) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008152305-A2 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | bioMérieux (FR) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008152306-A2 | NOVEL PEPTIDASE SUBSTRATES | bioMérieux (FR) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100221764-A1 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | CBR1, CBR3, XDH | APAF1 3880/4885ATM 4823/4885SAE1 829/4885 |
| US-20100099128-A1 | NOVEL PEPTIDASE SUBSTRATES | XPNPEP1, DPEP1, DDAH1 | APAF1 1053/4885ATM 4844/4885SAE1 249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.