Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Kuromanin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.98 |
| ▸ | CD38 | P28907 | 2/20 | 0.98 |
| ▸ | F2 | P00734 | 2/20 | 0.87 |
| ▸ | SNCA | P37840 | 1/20 | 0.52 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | P4HB | P07237 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Kuromanin SCHEMBL29762023 | 1.00 | DPP4 (0.98) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL29377806 | 1.00 | DPP4 (0.98) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL440823 | 1.00 | DPP4 (0.98) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL158216 | 1.00 | DPP4 (0.98) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL29349461 | 1.00 | DPP4 (0.98) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL3765133 | 0.99 | DPP4 (0.96) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL625949 | 0.99 | DPP4 (0.96) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL288591 | 0.99 | CD38 (1.00) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL1097555 | 0.99 | CD38 (1.00) | DPP4CD38F2SNCAGLO1 | |
| Kuromanin SCHEMBL1096430 | 0.99 | CD38 (1.00) | DPP4CD38F2SNCAGLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 135 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023219526-A1 | MULTITARGET ANTIVIRAL DIETARY SUPPLEMENT | PROKIN MILAN (RS) | 2023-11-16 | — | — | WO | claimed |
| EP-2976061-B1 | COMBINATIONS OF N-ACETYL CYSTEINE DERIVATIVES AND CRANBERRY POLYPHENOLS IN COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING PERIODONTAL DISEASES AND PERI-IMPLATITIS | DENTALMED PHARM HOLDING LTD (BE) | 2019-10-16 | — | — | EP | claimed |
| US-20160279043-A1 | COMBINATIONS OF N-ACETYL CYSTEINE DERIVATIVES AND CRANBERRY POLYPHENOLS IN COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING PERIODONTAL DISEASES AND PERI-IMPLATITIS | DENTALMED PHARM HOLDING LTD. (BE) | 2016-09-29 | — | — | US | claimed |
| EP-2976061-A1 | COMBINATIONS OF N-ACETYL CYSTEINE DERIVATIVES AND CRANBERRY POLYPHENOLS IN COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING PERIODONTAL DISEASES AND PERI-IMPLATITIS | Dentalmed Pharm Holding Ltd. (BE) | 2016-01-27 | — | — | EP | claimed |
| WO-2014147613-A1 | COMBINATIONS OF N-ACETYL CYSTEINE DERIVATIVES AND CRANBERRY POLYPHENOLS IN COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING PERIODONTAL DISEASES AND PERI-IMPLATITIS | DENTALMED PHARM HOLDING LTD. (BE) | 2014-09-25 | — | — | WO | claimed |
| CN-102245177-A | Oral composition | UNILEVER NV | 2011-11-16 | — | — | CN | claimed |
| WO-2011130719-A2 | A BIOSYNTHETIC PATHWAY FOR HETEROLOGOUS EXPRESSION OF A NONRIBOSOMAL PEPTIDE SYNTHETASE DRUG AND ANALOGS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-10-20 | — | — | WO | claimed |
| US-20110237660-A1 | ORAL COMPOSITION | CONOPCO, INC., D/B/A UNILEVER | 2011-09-29 | — | — | US | claimed |
| EP-2365807-A1 | ORAL COMPOSITION | Unilever PLC (GB) | 2011-09-21 | — | — | EP | claimed |
| US-7887868-B2 | low-salt soy sauce having an antihypertensive effect; contains 3.55% or less by weight of sodium, 0.5% to 3.6% by weight of potassium, 0.05 to 20% by weight of at least one polyphenol | KAO CORPORATION (JP) | 2011-02-15 | — | — | US | claimed |
| WO-2010066641-A1 | ORAL COMPOSITION | UNILEVER PLC (GB) | 2010-06-17 | — | — | WO | claimed |
| US-7727524-B2 | Low sodium liquid seasoning with anti-hypertensive activity | KAO CORPORATION (JP) | 2010-06-01 | — | — | US | claimed |
| CN-2433670-Y | Physical isolator suitable for computer network | LIANG YANWEN (CN) | 2001-06-06 | — | — | CN | claimed |
| EP-0496349-B1 | Coating solution for preventing adhesion of polymer scale and method for its use | SHINETSU CHEMICAL CO (JP) | 1996-04-10 | — | — | EP | claimed |
| EP-0496349-A1 | Coating solution for preventing adhesion of polymer scale and method for its use | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1992-07-29 | — | — | EP | claimed |
| WO-2025070135-A1 | HEXAVALENT-CHROMIUM-REDUCING PHOTOCATALYST COMPOSITION AND METHOD FOR REDUCING HEXAVALENT CHROMIUM | ユシロ化学工業株式会社 | 2025-04-03 | — | — | WO | disclosed |
| CN-113881685-B | Gene PpHSP20-like1 for promoting plant organ to produce red color and application thereof | 江苏省农业科学院 | 2024-03-29 | — | — | CN | disclosed |
| US-5241022-A | Polyvinyl alcohol with saponification of not less than seventy percent and quinone | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1993-08-31 | — | — | US | disclosed |
| EP-0496349-A1 | Coating solution for preventing adhesion of polymer scale and method for its use | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1992-07-29 | — | — | EP | disclosed |
| EP-0397879-A1 | METHOD FOR DETECTING GLYCOSIDICALLY LINKED LOW-MOLECULAR COMPOUND BY IMMUNOASSAY | P.C.C. TECHNOLOGY INC. (JP) | 1990-11-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160279043-A1 | COMBINATIONS OF N-ACETYL CYSTEINE DERIVATIVES AND CRANBERRY POLYPHENOLS IN COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING PERIODONTAL DISEASES AND PERI-IMPLATITIS | SIRT3, NNT, SIRT1 | DPP4 866/4885CD38 253/4885F2 752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.