Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fosfomycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fosfomycin SCHEMBL3168929 | 1.00 | — | — | |
| Fosfomycin SCHEMBL8633252 | 1.00 | — | — | |
| Fosfomycin SCHEMBL9634477 | 1.00 | — | — | |
| Fosfomycin SCHEMBL10492648 | 1.00 | — | — | |
| Fosfomycin SCHEMBL989825 | 1.00 | — | — | |
| Fosfomycin SCHEMBL50951 | 1.00 | — | — | |
| Fosfomycin SCHEMBL5595663 | 1.00 | LMNA (0.50) | — | |
| Fosfomycin SCHEMBL989824 | 0.97 | — | — | |
| Fosfomycin SCHEMBL9634052 | 0.97 | LMNA (0.48) | — | |
| Fosfomycin SCHEMBL20597804 | 0.97 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5191094-A | Mono (2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate with improved characteristics of stability and processing | ZAMBON GROUP S.P.A. (IT) | 1993-03-02 | — | — | US | claimed |
| US-5162309-A | Urogenital disorders | ZAMBON GROUP (IT) | 1992-11-10 | — | — | US | claimed |
| EP-0299484-A1 | Process for the preparation of intermediates for the synthesis of fosfomycin | ZAMBON GROUP S.p.A. (IT) | 1989-01-18 | — | — | EP | claimed |
| JP-58134028-A | — | — | None | — | — | JP | disclosed |
| EP-4678176-A1 | AMINO ACID SALTS OF FOSFOMYCIN AND COMPOSITIONS THEREOF | Ercros, S.A. (ES) | 2026-01-14 | — | — | EP | disclosed |
| EP-3220920-B1 | COMBINATION THERAPY EFFECTIVE AGAINST MICROORGANISMS, INCLUDING DRUG RESISTANT MICROORGANISMS | FLEURIR ABX LLC (US) | 2025-06-04 | — | — | EP | disclosed |
| US-20240293434-A1 | COMBINATION THERAPY EFFECTIVE AGAINST MICROORGANISMS, INCLUDING DRUG RESISTANT MICROORGANISMS | FLEURIR ABX LLC (US) | 2024-09-05 | — | — | US | disclosed |
| US-11925653-B2 | Combination therapy effective against microorganisms, including drug resistant microorganisms | FLEURIR ABX, LLC (US) | 2024-03-12 | — | — | US | disclosed |
| US-11833250-B2 | Fosfomycin tablet formulations | LABIANA HEALTH, S.L. (ES) | 2023-12-05 | — | — | US | disclosed |
| US-20220233557-A1 | Combination Therapy Effective Against Microorganisms, Including Drug Resistant Microorganisms | FLEURIR ABX LLC (US) | 2022-07-28 | — | — | US | disclosed |
| US-10980811-B2 | Reversal of fosfomycin resistance | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2021-04-20 | — | — | US | disclosed |
| US-4479898-A | Oligopeptide prodrugs | SMITHKLINE BECKMAN CORPORATION (US) | 1984-10-30 | — | — | US | disclosed |
| US-4454065-A | INCREASE CELL MEMBRANE PERMEABILITY | SMITHKLINE BECKMAN CORPORATION (US) | 1984-06-12 | — | — | US | disclosed |
| JP-S58134028-A | AGENT FOR MITIGATING OR PREVENTING RENAL TOXICITY OF AMINOGLUCOSIDE ANTIBIOTIC SUBSTANCE | MEIJI SEIKA KAISHA LTD | 1983-08-10 | — | — | JP | disclosed |
| US-3943153-A | BACTERICIDES | MERCK & CO., INC. (US) | 1976-03-09 | — | — | US | disclosed |
| US-3943153-A | BACTERICIDES | MERCK & CO., INC. (US) | 1976-03-09 | — | — | US | disclosed |
| US-3935309-A | CHLORAMPHENICOL | MERCK & CO., INC. (US) | 1976-01-27 | — | — | US | disclosed |
| US-3929840-A | Labile esters of ({31 )(cis-1,2-epoxypropyl)phosphonic | MERCK & CO INC | 1975-12-30 | — | — | US | disclosed |
| US-3914231-A | ({31 )(Cis-1,2-epoxypropyl)-phosphonic acid and salts thereof | MERCK & CO INC | 1975-10-21 | — | — | US | disclosed |
| US-3862148-A | P-(-)-(CIS-1,2-EPOXYPROPYL)-ISOHYPOPHOSPHORIC ACID COMPOUNDS | MERCK & CO INC | 1975-01-21 | — | — | US | disclosed |