Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fosfomycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fosfomycin SCHEMBL788599 | 1.00 | LMNA (0.48) | LMNAMAPTBLMPMP22CYP2C9 | |
| Fosfomycin SCHEMBL1442686 | 1.00 | — | — | |
| Fosfomycin SCHEMBL3168929 | 0.97 | — | — | |
| Fosfomycin SCHEMBL8633252 | 0.97 | — | — | |
| Fosfomycin SCHEMBL3168937 | 0.97 | — | — | |
| Fosfomycin SCHEMBL9634477 | 0.97 | — | — | |
| Fosfomycin SCHEMBL10492648 | 0.97 | — | — | |
| Fosfomycin SCHEMBL989825 | 0.97 | — | — | |
| Fosfomycin SCHEMBL5595663 | 0.97 | LMNA (0.50) | LMNAMAPTBLMPMP22CYP2C9 | |
| Fosfomycin SCHEMBL50951 | 0.97 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0251324-B1 | PROCESS FOR THE PREPARATION OF ANTIBIOTICS | ZAMBON S.p.A. (IT) | 1992-05-06 | — | — | EP | disclosed |
| EP-0251324-A2 | Process for the preparation of antibiotics | ZAMBON S.p.A. (IT) | 1988-01-07 | — | — | EP | disclosed |