Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL316187 | 0.77 | NPC1 (0.43) | L3MBTL1KDM4ELMNANPC1RAB9A | |
| SCHEMBL316570 | 0.74 | ALDH1A1 (0.56) | L3MBTL1KDM4ELMNARAB9ASLC6A12 | |
| SCHEMBL316160 | 0.74 | ALDH1A1 (0.50) | LMNAPOLBALDH1A1MAPTMAPK1 | |
| SCHEMBL2987821 | 0.73 | ATF4 (0.58) | LMNARAB9APOLBALDH1A1ACHE | |
| SCHEMBL315428 | 0.73 | GHSR (0.56) | KDM4ELMNAALDH1A1MAPT | |
| SCHEMBL315461 | 0.72 | KMT2A (0.65) | L3MBTL1LMNAALDH1A1MAPT | |
| SCHEMBL316302 | 0.72 | GHSR (0.56) | KDM4EALDH1A1MAPT | |
| SCHEMBL2985500 | 0.72 | ATF4 (0.57) | LMNARAB9APOLBALDH1A1ACHE | |
| SCHEMBL2982759 | 0.72 | ATF4 (0.57) | LMNARAB9APOLBALDH1A1ACHE | |
| SCHEMBL2987752 | 0.72 | CNR2 (0.42) | L3MBTL1KDM4ELMNAPOLBDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093272-B2 | Heteroaryl substituted cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2012-01-10 | — | — | US | claimed |
| US-8093272-B2 | Heteroaryl substituted cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2012-01-10 | — | — | US | disclosed |