Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 8/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3161730 | 0.91 | ADORA2A (0.48) | RAB9ASMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL3156424 | 0.90 | ADORA2A (0.46) | NAMPTNPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL3155990 | 0.85 | L3MBTL1 (0.50) | ADORA3NAMPTNPC1RAB9AL3MBTL1 | |
| SCHEMBL3163156 | 0.83 | RAB9A (0.48) | ADORA3NPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL3164704 | 0.83 | GBA1 (0.42) | ADORA3SMN1; SMN2ADORA2AADORA1HRH4 | |
| SCHEMBL3176983 | 0.82 | ADORA3 (0.57) | ADORA3NPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL3170845 | 0.82 | ADORA3 (0.46) | ADORA3NPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL3168952 | 0.81 | ADORA3 (0.43) | ADORA3NPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL3163147 | 0.81 | ALDH1A1 (0.50) | ADORA3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL3171162 | 0.80 | ADORA2A (0.56) | ADORA3SMN1; SMN2ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |
| EP-1465631-A4 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1465631-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI Pharmaceuticals, Inc. (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003053366-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARMACEUTICALS, INC. (US) | 2003-07-03 | — | — | WO | disclosed |