Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 7/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31706629 | 0.91 | GRM5 (0.40) | HSD11B1ALDH1A1TSHRGRM5PROKR1 | |
| Lithium Ion SCHEMBL31705499 | 0.87 | NAMPT (0.40) | ALDH1A1 | |
| SCHEMBL31704500 | 0.83 | ALDH1A1 (0.39) | HSD11B1KDM4EPDE2AALDH1A1GRM5 | |
| Lithium Ion SCHEMBL31705741 | 0.77 | NAMPT (0.41) | KDM4EHTTALDH1A1TSHR | |
| Lithium Ion SCHEMBL31705507 | 0.77 | NAMPT (0.30) | — | |
| SCHEMBL31705001 | 0.76 | PROKR1 (0.41) | ALDH1A1TSHRGRM5PROKR1 | |
| Lithium Ion SCHEMBL31706119 | 0.76 | NAMPT (0.39) | — | |
| Lithium Ion SCHEMBL31705497 | 0.76 | NAMPT (0.39) | — | |
| SCHEMBL31705199 | 0.74 | NAMPT (0.41) | ALDH1A1TSHR | |
| SCHEMBL31704523 | 0.70 | ALDH1A1 (0.42) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |