Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31705264 | 0.91 | HSD11B1 (0.38) | GRM5PROKR1ALDH1A1TSHRHSD11B1 | |
| SCHEMBL31705001 | 0.86 | PROKR1 (0.41) | GRM5PROKR1ALDH1A1TSHR | |
| Lithium Ion SCHEMBL31705499 | 0.78 | NAMPT (0.40) | ALDH1A1 | |
| SCHEMBL31704500 | 0.77 | ALDH1A1 (0.39) | GRM5PROKR1ALDH1A1HSD11B1MAPT | |
| Lithium Ion SCHEMBL31705741 | 0.71 | NAMPT (0.41) | ALDH1A1TSHR | |
| Lithium Ion SCHEMBL31706036 | 0.70 | MYC (0.33) | GRM5ALDH1A1MYC | |
| Lithium Ion SCHEMBL31705497 | 0.70 | NAMPT (0.39) | — | |
| Lithium Ion SCHEMBL31706119 | 0.70 | NAMPT (0.39) | — | |
| Lithium Ion SCHEMBL31705507 | 0.69 | NAMPT (0.30) | — | |
| SCHEMBL31705199 | 0.66 | NAMPT (0.41) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |