Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
| ▸ | QDPR | P09417 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31705264 | 0.87 | HSD11B1 (0.38) | ALDH1A1 | |
| Lithium Ion SCHEMBL31705497 | 0.87 | NAMPT (0.39) | NAMPTTNKSTNKS2HTR2BTLR9 | |
| Lithium Ion SCHEMBL31706119 | 0.87 | NAMPT (0.39) | NAMPTTNKSTNKS2HTR2BTLR9 | |
| SCHEMBL31705199 | 0.86 | NAMPT (0.41) | NAMPTTNKSTNKS2HTR2BTLR9 | |
| SCHEMBL31704958 | 0.82 | ALDH1A1 (0.42) | NAMPTALDH1A1POLBCHRM4CHRM1 | |
| SCHEMBL31704523 | 0.82 | ALDH1A1 (0.42) | NAMPTALDH1A1POLBCHRM4CHRM1 | |
| Lithium Ion SCHEMBL31705507 | 0.81 | NAMPT (0.30) | NAMPT | |
| Lithium Ion SCHEMBL31705741 | 0.81 | NAMPT (0.41) | NAMPTALDH1A1 | |
| Lithium Ion SCHEMBL31706176 | 0.80 | NAMPT (0.38) | NAMPTTNKSTNKS2TLR9TLR8 | |
| Lithium Ion SCHEMBL31704614 | 0.80 | NAMPT (0.38) | NAMPTTNKSTNKS2TLR9TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |