Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31705035 | 0.89 | MAPT (0.39) | TDP1MAPTALDH1A1POLBNPSR1 | |
| SCHEMBL31705062 | 0.85 | ALDH1A1 (0.37) | TDP1MAPTALDH1A1NPSR1SMN1; SMN2 | |
| Lithium Ion SCHEMBL31706117 | 0.78 | CHRM1 (0.40) | TDP1MAPTALDH1A1POLBSMN1; SMN2 | |
| Lithium Ion SCHEMBL31704746 | 0.78 | CHRM1 (0.40) | TDP1MAPTALDH1A1POLBSMN1; SMN2 | |
| Lithium Ion SCHEMBL31705638 | 0.77 | DGAT2 (0.35) | ALDH1A1POLBSMN1; SMN2HPGDHSD17B10 | |
| Lithium Ion SCHEMBL31706463 | 0.77 | DGAT2 (0.35) | ALDH1A1POLBSMN1; SMN2HPGDHSD17B10 | |
| Lithium Ion SCHEMBL31706365 | 0.73 | CHRNB2 (0.41) | TDP1MAPTALDH1A1SMN1; SMN2MEN1 | |
| Lithium Ion SCHEMBL31706547 | 0.72 | NAMPT (0.47) | TDP1MAPTALDH1A1SMN1; SMN2MEN1 | |
| Potassium Ion SCHEMBL31705065 | 0.71 | CKS1B (0.39) | TDP1MAPTALDH1A1SMN1; SMN2MEN1 | |
| Lithium Ion SCHEMBL31705981 | 0.69 | TDP1 (0.51) | TDP1MAPTALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |