Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | GPR3 | P46089 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL8935403 | 0.98 | HTR2A (0.33) | HTR2ACYP19A1 | |
| Hydrochloric Acid SCHEMBL2483036 | 0.87 | SLC6A2 (0.36) | HTR2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL7129103 | 0.83 | SLC6A2 (0.32) | CYP19A1 | |
| Hydrochloric Acid SCHEMBL6557429 | 0.82 | KDM1A (0.34) | — | |
| Hydrochloric Acid SCHEMBL9412837 | 0.81 | NR3C1 (0.39) | HTR2ACYP19A1 | |
| Hydrochloric Acid SCHEMBL6559838 | 0.80 | ALDH1A1 (0.30) | — | |
| Hydrochloric Acid SCHEMBL7938541 | 0.79 | HTR2A (0.34) | HTR2ACYP19A1GPR3CYP1A2CYP2D6 | |
| Methane SCHEMBL8163328 | 0.77 | HTR2A (0.33) | HTR2ACYP19A1 | |
| Hydrochloric Acid SCHEMBL8905301 | 0.77 | HTR2A (0.33) | HTR2ACYP19A1GPR3 | |
| Hydrochloric Acid SCHEMBL8678196 | 0.77 | GRM5 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8759243-B2 | Multi-component catalyst systems and polymerization processes for forming in-situ heterophasic copolymers and/or varying the xylene solubles content of polyolefins | FINA TECHNOLOGY, INC. (US) | 2014-06-24 | — | — | US | claimed |
| US-20130102743-A9 | MULTI-COMPONENT CATALYST SYSTEMS AND POLYMERIZATION PROCESSES FOR FORMING IN-SITU HETEROPHASIC COPOLYMERS AND/OR VARYING THE XYLENE SOLUBLES CONTENT OF POLYOLEFINS | FINA TECHNOLOGY, INC. (US) | 2013-04-25 | — | — | US | claimed |
| EP-2201043-A1 | MULTI-COMPONENT CATALYST SYSTEMS AND POLYMERIZATION PROCESSES FOR FORMING IN-SITU HETEROPHASIC COPOLYMERS AND/OR VARYING THE XYLENE SOLUBLES CONTENT OF POLYOLEFINS | Fina Technology, Inc. (US) | 2010-06-30 | — | — | EP | claimed |
| US-20090105433-A1 | Multi-component catalyst systems and polymerization processes for forming in-situ heterophasic copolymers and/or varying the xylene solubles content of polyolefins | FINA TECHNOLOGY, INC. (US) | 2009-04-23 | — | — | US | claimed |
| WO-2009052146-A1 | MULTI-COMPONENT CATALYST SYSTEMS AND POLYMERIZATION PROCESSES FOR FORMING IN-SITU HETEROPHASIC COPOLYMERS AND/OR VARYING THE XYLENE SOLUBLES CONTENT OF POLYOLEFINS | FINA TECHNOLOGY, INC. (US) | 2009-04-23 | — | — | WO | claimed |
| US-5914376-A | Catalyst for the polymerization of olefins, process for the preparation thereof, and use thereof | TARGOR GMBH (DE) | 1999-06-22 | — | — | US | claimed |
| US-5627247-A | COMPOUNDS OF CYCLOPENTADIENE OR INDENE WITH FLUORENE AND GROUP IV METALS | PHILLIPS PETROLEUM COMPANY (US) | 1997-05-06 | — | — | US | claimed |
| US-8759243-B2 | Multi-component catalyst systems and polymerization processes for forming in-situ heterophasic copolymers and/or varying the xylene solubles content of polyolefins | FINA TECHNOLOGY, INC. (US) | 2014-06-24 | — | — | US | disclosed |
| US-20130102743-A9 | MULTI-COMPONENT CATALYST SYSTEMS AND POLYMERIZATION PROCESSES FOR FORMING IN-SITU HETEROPHASIC COPOLYMERS AND/OR VARYING THE XYLENE SOLUBLES CONTENT OF POLYOLEFINS | FINA TECHNOLOGY, INC. (US) | 2013-04-25 | — | — | US | disclosed |
| EP-2204375-A1 | Preparation of mono-aryl-substituted methylene-bridged substituted cyclopentadienyl-fluorenyl ligands and zirconium complexes derived thereof | Total Petrochemicals Research Feluy (BE) | 2010-07-07 | — | — | EP | disclosed |
| EP-2201043-A1 | MULTI-COMPONENT CATALYST SYSTEMS AND POLYMERIZATION PROCESSES FOR FORMING IN-SITU HETEROPHASIC COPOLYMERS AND/OR VARYING THE XYLENE SOLUBLES CONTENT OF POLYOLEFINS | Fina Technology, Inc. (US) | 2010-06-30 | — | — | EP | disclosed |
| US-20100016528-A1 | Ethylene and alpha-olefins polymerisation catalyst system based on fluorenyl ligand | FINA TECHNOLOGY, INC. (US) | 2010-01-21 | — | — | US | disclosed |
| EP-2069372-A1 | PREPARATION OF DIPHENYL-BRIDGED SUBSTITUTED CYCLOPENTADIENYL-FLUORENYL LIGANDS | TOTAL PETROCHEMICALS RESEARCH FELUY (BE) | 2009-06-17 | — | — | EP | disclosed |
| US-5594078-A | BRIDGED FLUORENYL METALLOCENE CATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0747403-A1 | A process for producing an isotactic/syndiotactic polymer blend in a single reactor | FINA TECHNOLOGY, INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| US-5534473-A | METALLOCENES AND COCATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1996-07-09 | — | — | US | disclosed |
| EP-0705851-A2 | Catalyst systems and process for producing broad molecular weight distribution polyolefin | PHILLIPS PETROLEUM COMPANY (US) | 1996-04-10 | — | — | EP | disclosed |
| US-5476914-A | Highly crystalline; comprising a high percentage of racemic dyads | FINA TECHNOLOGY, INC. (US) | 1995-12-19 | — | — | US | disclosed |
| US-5359001-A | Block polymers with improved mechanical properties | HOECHST AKTIENGESELLSCHAFT | 1994-10-25 | — | — | US | disclosed |
| WO-1992012184-A1 | SYNDIOTACTIC POLYPROPYLENE | EXXON CHEMICAL PATENTS INC. (US) | 1992-07-23 | — | — | WO | disclosed |