Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8906349 | 0.96 | HTR2A (0.35) | HTR2AGPR3SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL7938541 | 0.77 | HTR2A (0.34) | HTR2AGPR3CYP19A1 | |
| Hydrochloric Acid SCHEMBL3170692 | 0.77 | HTR2A (0.34) | HTR2AGPR3CYP19A1 | |
| Methane SCHEMBL8935403 | 0.76 | HTR2A (0.33) | HTR2ACYP19A1 | |
| Methane SCHEMBL8163328 | 0.76 | HTR2A (0.33) | HTR2ACYP19A1 | |
| Methane SCHEMBL8935426 | 0.76 | GPR3 (0.31) | HTR2AGPR3SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL3687523 | 0.73 | HTR2A (0.32) | HTR2A | |
| Hydrochloric Acid SCHEMBL2763539 | 0.73 | SLC6A2 (0.31) | SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL3679754 | 0.73 | ADRA2C (0.31) | — | |
| Hydrochloric Acid SCHEMBL8838234 | 0.72 | SLC6A2 (0.31) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5622906-A | CONTACTING TRANSITION METAL CONTAINING CATALYST WITH ORGANOALUMINOXANE DISPERSED IN SOLVENT, COMBINING SLURRY FORMED WITH BOROXIN COMPOUND, CONTACTING WITH METALLOCENE TO FORM OLEFIN POLYMERIZATION CATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1997-04-22 | — | — | US | disclosed |
| EP-0705848-A2 | Compositions useful for olefin polymerization and processes therefor and therewith | PHILLIPS PETROLEUM COMPANY (US) | 1996-04-10 | — | — | EP | disclosed |