Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 6/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.33 |
| ▸ | STAMBP | O95630 | 1/20 | 0.33 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20722502 | 0.83 | NNMT (0.43) | NNMTCYP11B2SMN1; SMN2AKT1KDM4E | |
| SCHEMBL31712856 | 0.81 | NNMT (0.40) | NNMTSMN1; SMN2PSMD14STAMBPCOPS5 | |
| SCHEMBL31712871 | 0.79 | NNMT (0.40) | NNMTCYP11B2SMN1; SMN2MAPTRAB9A | |
| SCHEMBL26607684 | 0.72 | NNMT (0.58) | NNMTCYP11B2SMN1; SMN2MAPTRAB9A | |
| SCHEMBL31712899 | 0.72 | SIRT6 (0.37) | NNMTCYP11B2SMN1; SMN2MAPTRAB9A | |
| SCHEMBL17675163 | 0.69 | NNMT (0.58) | NNMTCYP11B2SMN1; SMN2MAPTRAB9A | |
| SCHEMBL30450524 | 0.68 | SIRT3 (0.43) | NNMTCYP11B2MAPTKDM4E | |
| SCHEMBL29106373 | 0.68 | KDM4E (0.38) | KDM4EPSMD14 | |
| SCHEMBL29056855 | 0.67 | POLB (0.38) | NNMTCYP11B2SMN1; SMN2MAPTRAB9A | |
| SCHEMBL25275289 | 0.66 | NNMT (0.38) | NNMTHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4251624-B1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC (US) | 2025-10-29 | — | — | EP | claimed |