Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | NNMT | P40261 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29875709 | 0.81 | LCK (0.35) | SIRT6LCKCHEK1PDE4APDE4B | |
| SCHEMBL31712871 | 0.78 | NNMT (0.40) | NNMTNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL31712880 | 0.75 | PARP1 (0.39) | SIRT6LCKNNMTCHEK1PDE4B | |
| SCHEMBL18248727 | 0.74 | NOS3 (0.52) | SIRT6LCKNNMTNPC1MAPT | |
| SCHEMBL31712859 | 0.72 | NNMT (0.48) | NNMTNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL31712846 | 0.69 | LCK (0.40) | SIRT6LCKADORA3TSHRMC4R | |
| SCHEMBL24468454 | 0.67 | KMT2A (0.35) | SMN1; SMN2TP53KDM4EACHETSHR | |
| SCHEMBL28234630 | 0.66 | LCK (0.39) | LCKNPC1RAB9AACHEPDE4D | |
| SCHEMBL19641430 | 0.66 | SIRT6 (0.40) | SIRT6LCKNNMTSMN1; SMN2CHEK1 | |
| SCHEMBL30036680 | 0.66 | SIRT6 (0.40) | SIRT6LCKNNMTSMN1; SMN2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4251624-B1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC (US) | 2025-10-29 | — | — | EP | claimed |