Cytochalasin D

Cytochalasin D

SCHEMBL31734099

C=C1C(C)C2C(Cc3ccccc3)NC(=O)C23C(OC(C)=O)C=CC(C)(O)C(=O)C(C)CC=CC3C1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR0B1 P51843 1/20 1.00
ADORA3 P0DMS8 1/20 0.79
CCR5 P51681 1/20 0.52
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
NPC1 O15118 2/20 0.46
LMNA P02545 1/20 0.46
SLC2A1 P11166 1/20 0.46
SLC2A2 P11168 1/20 0.46
SLC2A3 P11169 1/20 0.46
SLC2A4 P14672 1/20 0.46
MAPK1 P28482 1/20 0.46
RAB9A P51151 1/20 0.46
SLC2A9 Q9NRM0 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
HIF1A Q16665 1/20 0.46
PAX8 Q06710 1/20 0.46
ABCB1 P08183 8/20 0.33
CYP3A4 P08684 1/20 0.32
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cytochalasin D SCHEMBL33528 1.00 NR0B1 (1.00) NR0B1ADORA3CCR5MEN1KMT2A
Cytochalasin D SCHEMBL16502284 1.00 NR0B1 (1.00) NR0B1ADORA3CCR5MEN1KMT2A
Cytochalasin D SCHEMBL33529 1.00 NR0B1 (1.00) NR0B1ADORA3CCR5MEN1KMT2A
Cytochalasin D SCHEMBL29375699 1.00 NR0B1 (1.00) NR0B1ADORA3CCR5MEN1KMT2A
Cytochalasin D SCHEMBL25847004 1.00 NR0B1 (1.00) NR0B1ADORA3CCR5MEN1KMT2A
Cytochalasin D SCHEMBL12648577 1.00 NR0B1 (1.00) NR0B1ADORA3CCR5MEN1KMT2A
SCHEMBL29745878 0.93 NR0B1 (0.86) NR0B1ADORA3CCR5MEN1KMT2A
Zygosporin D SCHEMBL34014 0.89 NR0B1 (0.80) NR0B1ADORA3CCR5MEN1KMT2A
SCHEMBL22621306 0.88 NR0B1 (0.79) NR0B1ADORA3CCR5MEN1KMT2A
SCHEMBL33708 0.88 ADORA3 (1.00) NR0B1ADORA3CCR5MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3350313-B1 DERIVATION OF LIVER ORGANOIDS FROM HUMAN PLURIPOTENT STEM CELLS AGENCY FOR SCIENCE TECH AND RESEARCH ASTARSTAR (SG) 2025-11-26 EP claimed
EP-3350313-B1 DERIVATION OF LIVER ORGANOIDS FROM HUMAN PLURIPOTENT STEM CELLS AGENCY FOR SCIENCE TECH AND RESEARCH ASTARSTAR (SG) 2025-11-26 EP disclosed